Advances in Experimental Medicine and Biology

Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology

Editors: Corbeil, Denis (Ed.)

  • ​Provides exciting new research on prominin-1/CD133 and its role in expression in cancer stem cells
  • ​​​​​Explores the role of the prominin family and presents new information regarding the regulation of prominin-1 ​
  • Evaluates prominin-1/CD133 as a stem cell marker for cancers and other diseases and presents future prospects for its potential role in regenerative therapy
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eBook $169.00
price for USA (gross)
  • ISBN 978-1-4614-5894-4
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  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4614-5893-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-1-4899-8692-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

​​​​​​​Prominin-1 or otherwise known as CD133 is a glycoprotein that is present in humans and mice. Since the first description of prominin in 1997, in mouse neuroepithelial cells and in human hematopoietic stem cells as AC133 antigen, this molecule has aroused a large interest especially, as a stem cell marker, that gave rise to an ever growing body of publications and more recently its expression in cancer stem cells. Controversies as to its role as a cancer stem and its detection in different models, as well as its use as a prognostic marker have emerged. Yet, beyond its use as a stem cell and cancer stem cell marker, prominin-1/CD133 displays unique biological features and appears of importance in other processes like for example in retinal biogenesis. Indeed, this five-transmembrane plasma membrane glycoprotein, which marks membrane protrusions is associated with several essential processes like cell polarity, asymmetric cell division and membrane remodeling. We propose to review current knowledge about this intriguing molecule and present pertinent information to determine the biological role of prominins and assess their importance in medicine and cancer research. The primary audience for this book is geared towards scientists and researchers with interest in cancer stem cells, stem cells, cell biology, neurobiology, and regenerative medicine.

Table of contents (15 chapters)

  • Prominin-1 (CD133): Molecular and Cellular Features Across Species

    Corbeil, Denis (et al.)

    Pages 3-24

  • Prominin-2 and Other Relatives of CD133

    Fargeas, Christine A.

    Pages 25-40

  • Prominin-1-Containing Membrane Vesicles: Origins, Formation, and Utility

    Marzesco, Anne-Marie

    Pages 41-54

  • Prominent Role of Prominin in the Retina

    Gurudev, Nagananda (et al.)

    Pages 55-71

  • Gene Regulation of Prominin-1 (CD133) in Normal and Cancerous Tissues

    Tabu, Kouichi (et al.)

    Pages 73-85

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-1-4614-5894-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4614-5893-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-1-4899-8692-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology
Editors
  • Denis Corbeil
Series Title
Advances in Experimental Medicine and Biology
Series Volume
777
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-5894-4
DOI
10.1007/978-1-4614-5894-4
Hardcover ISBN
978-1-4614-5893-7
Softcover ISBN
978-1-4899-8692-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XVI, 252
Topics