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Biochemical Basis and Therapeutic Implications of Angiogenesis

  • Book
  • © 2013

Overview

Editors:
  1. Jawahar L. Mehta

    1. Div. of Cardiovascular Medicine, UAMS, Little Rock, AR, USA, Little Rock, USA

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  2. Naranjan S. Dhalla

    1. Institute of Cardiovascular Sciences, St. Boniface Hosp. Research, Univ. of Ma, Winnipeg, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides a comprehensive view of angiogenesis in diverse diseases
  • Explains the molecular mechanisms in atherosclerosis and diabetes, and examines the role of cellular and subcellular structures during the development of angiogenesis
  • Well established investigators update the existing literature and discusses various diverse issues for developing certain unifying concepts, thereby serving as a valuable source for discovering improved therapies

Part of the book series: Advances in Biochemistry in Health and Disease (ABHD, volume 6)

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Molecular Mechanisms of Angiogenesis

    1. Front Matter

      Pages 1-1
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    2. Endothelial Growth Factor Receptors in Angiogenesis

      • David J. Bruce, Peng H. Tan
      Pages 3-22

    3. Role of Transforming Growth Factor Beta in Angiogenesis

      • Alicia Viloria-Petit, Amy Richard, Sonja Zours, Mai Jarad, Brenda L. Coomber
      Pages 23-45

    4. Role of Cytokines in Angiogenesis: Turning It On and Off

      • Melissa A. Thal, Raj Kishore
      Pages 47-61

    5. Neuropeptides and Angiogenesis

      • Leena Pradhan-Nabzdyk, Christoph Nabzdyk
      Pages 63-77

    6. Role of Integrins in Angiogenesis

      • Ghazaleh Tabatabai, Michael Weller
      Pages 79-91

    7. Regulation of Angiogenesis by Hypoxia-Inducible Factors

      • Hideki Hayakawa, Futoshi Shibasaki
      Pages 93-106

    8. Role of Mast Cells in Angiogenesis

      • Enrico Crivellato, Domenico Ribatti
      Pages 107-121

    9. Vascular Stem Cells in Regulation of Angiogenesis

      • Jingwei Lu, Vincent J. Pompili, Hiranmoy Das
      Pages 123-138

    10. Toll-Like Receptor-Linked Signal Transduction in Angiogenesis

      • Karsten Grote, Harald Schütt, Bernhard Schieffer
      Pages 139-157

    11. Role of Sex Steroids in Angiogenesis

      • Laura Lecce, Yuen Ting Lam, Martin K. C. Ng
      Pages 159-180

    12. Biochemical Mechanisms of Exercise-Induced Angiogenesis

      • Dustin Scott Kehler, Naranjan S. Dhalla, Todd A. Duhamel
      Pages 181-206

  3. Pathophysiological Aspects of Angiogenesis

    1. Front Matter

      Pages 207-207
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    2. Angiogenesis in Atherosclerosis: An Overview

      • Sadip Pant, Abhishek Deshmukh, Jawahar L. Mehta
      Pages 209-224

    3. Role of Serotonin in Angiogenesis in Diabetes

      • Masaaki Iwabayashi, Yoshiaki Taniyama, Junya Azuma, Fumihiro Sanada, Kazuma Iekushi, Hiromi Rakugi et al.
      Pages 225-238

    4. Brain Angiogenesis After Stroke

      • Kazuhide Hayakawa, Ji Hae Seo, Nobukazu Miyamoto, Loc-Duyen D. Pham, Deepti Navaratna, Eng H. Lo et al.
      Pages 239-260

    5. Angiogenesis in Myocardial Ischemia

      • Yasuyuki Fujita, Takayuki Asahara, Atsuhiko Kawamoto
      Pages 261-283

    6. Adipose Tissue-Derived Mesenchymal Stem Cell and Angiogenesis in Ischemic Heart Disease

      • Lina Badimon, Blanca Oñate, Gemma Vilahur
      Pages 285-311

    7. Trials of Angiogenesis Therapy in Patients with Ischemic Heart Disease

      • Sandeep Singla, Jawahar L. Mehta
      Pages 313-334
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Keywords

About this book

Angiogenesis is a highly complex phenomenon where new blood vessels are formed for the supply of oxygen and nutrients in different organs of the body.  It plays a critical role in both physiological processes such as growth and development as well as pathological processes including cancer and different types of tumors.  Angiogenesis is also essential for the regeneration and survival of cells in several disease conditions such as ischemic heart disease (myocardial infarction), atherosclerosis, brain injury (stroke) and diabetes.  Since the mechanisms of angiogenesis are organ specific and differ among various diseases, it is proposed to devote one section of this book to the development of angiogenesis in some selected diseases such as cancer, ischemic heart disease, atherosclerosis, diabetes and stroke.  It is pointed out that extensive research work in this regard has been carried out in the area of cancer and heart disease, whereas relatively less attention has been paid to studying angiogenesis in other disease conditions.

Editors and Affiliations

  • Div. of Cardiovascular Medicine, UAMS, Little Rock, AR, USA, Little Rock, USA

    Jawahar L. Mehta

  • Institute of Cardiovascular Sciences, St. Boniface Hosp. Research, Univ. of Ma, Winnipeg, Canada

    Naranjan S. Dhalla

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