Cell Death in Biology and Diseases

Cell Death Signaling in Cancer Biology and Treatment

Editors: Johnson, Daniel (Ed.)

  • Describes state-of-the-art approaches and future opportunities for selective and efficient killing of tumor cells
  • Discusses preclinical and clinical approaches
  • Features development and application of novel agents and approaches
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eBook $159.00
price for USA (gross)
  • ISBN 978-1-4614-5847-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-4614-5846-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4939-0107-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

A key goal in the treatment of cancer is to achieve selective and efficient killing of tumor cells. The aim of Cell Death Signaling in Cancer Biology and Treatment is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described. The potential for targeting microRNAs will be discussed. Multiple chapters will describe preclinical and clinical approaches that are currently being used to target epigenetic modifications, DNA repair pathways, and protein chaperones, as a means of provoking tumor cell death. Finally, the development and application of novel agents and approaches for targeting specific components of cell death signaling pathways and machinery will be reviewed.

About the authors

Dr. Daniel E. Johnson received his undergraduate training at North Park University and his doctoral degree in molecular biology from Princeton University.  He was a postdoctoral fellow at the University of California San Francisco.  In 1993 he joined the faculty at the University of Pittsburgh and the University of Pittsburgh Cancer Institute, where he is currently a Professor in the Departments of Medicine and Pharmacology & Chemical Biology.  Dr. Johnson has served as a standing member on study sections for the National Institutes of Health and American Cancer Society, and is a long-standing Section Editor for the journal Leukemia.  His research has focused on molecular mechanisms of apoptosis in leukemia and head and neck cancer, as well as the mechanisms of myeloid differentiation.  He has placed particular emphasis on the translation of findings from his laboratory to the clinic, and together with physician scientist collaborators has helped develop ongoing trials in both acute myeloid leukemia and head and neck cancer. 

Table of contents (14 chapters)

  • Defective Apoptosis Signaling in Cancer

    Johnson, Daniel E.

    Pages 1-34

  • The Warburg Effect and Beyond: Metabolic Dependencies for Cancer Cells

    Hockenbery, David M (et al.)

    Pages 35-51

  • Emerging Opportunities for Targeting the Tumor–Stroma Interactions for Increasing the Efficacy of Chemotherapy

    Nair, Rajesh R. (et al.)

    Pages 53-86

  • The Role of Autophagy in Drug Resistance and Potential for Therapeutic Targeting

    Rangwala, Reshma (et al.)

    Pages 87-116

  • MicroRNAs in Cell Death and Cancer

    Park, Jong Kook (et al.)

    Pages 117-136

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-1-4614-5847-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-4614-5846-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4939-0107-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cell Death Signaling in Cancer Biology and Treatment
Editors
  • Daniel Johnson
Series Title
Cell Death in Biology and Diseases
Copyright
2013
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-5847-0
DOI
10.1007/978-1-4614-5847-0
Hardcover ISBN
978-1-4614-5846-3
Softcover ISBN
978-1-4939-0107-4
Edition Number
1
Number of Pages
XVI, 408
Topics