Stem Cell Biology and Regenerative Medicine

The Immunological Barriers to Regenerative Medicine

Editors: Fairchild, Paul J. (Ed.)

  • Explores the extent to which the principles of allograft rejection, learned over several decades from our experiences of whole organ transplantation, apply within the unique context of cell replacement therapy
  • Discusses various innovative ways of addressing the issues of immunogenicity
  • Focuses exclusively on the induction of immunological tolerance through a variety of novel approaches
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  • ISBN 978-1-4614-5480-9
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Hardcover $209.00
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  • ISBN 978-1-4614-5479-3
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Softcover $209.00
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  • ISBN 978-1-4899-9932-0
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About this book

This volume offers an analysis of the scale and nature of the immunological issues facing regenerative medicine, drawing on the expertise of laboratories around the world who have taken up the challenge of applying their expertise in immunology to the vagaries of stem cell biology. In Part I, we explore the extent to which the principles of allograft rejection, learned over several decades from our experiences of whole organ transplantation, apply within the unique context of cell replacement therapy. Part II discusses various innovative ways of addressing the issues of immunogenicity, while, in Part III, we focus exclusively on the induction of immunological tolerance through a variety of novel approaches. It is our hope that this systematic analysis of the current state of the field will galvanise efforts to solve an issue which has so far remained intractable.

About the authors

Dr. Paul Fairchild began his research career in Oxford, where he studied for a doctorate within the Nuffield Department of Surgical Sciences, where his research focused on the immune response to organ allografts.  After spending five years as a post-doctoral fellow investigating the etiology of autoimmune disease in the Department of Pathology, University of Cambridge, he returned to Oxford, where he is currently a University Lecturer in Pre-clinical Medicine within the Sir William Dunn School of Pathology and a Fellow of Trinity College.  In 2008, Paul Fairchild founded the Oxford Stem Cell Institute (OSCI), for which he currently serves as Co-Director.  As a highly interdisciplinary organization, the OSCI focuses on exploiting the properties of stem cells for the treatment of some of the most intractable chronic and degenerative diseases.  It is within this context that he continues to apply his background in transplantation immunology, in order to investigate the nature of the immune response to tissues differentiated from pluripotent stem cells, and develop approaches to the induction and maintenance of immunological tolerance.

Table of contents (16 chapters)

  • Mechanisms of Immune Rejection of Stem Cell-Derived Tissues: Insights From Organ Transplantation

    Bolton, Eleanor M. (et al.)

    Pages 3-36

  • The Immunogenicity of Embryonic Stem Cells and Their Differentiated Progeny

    Pearl, Jeremy I. (et al.)

    Pages 37-48

  • Interaction of Embryonic Stem Cells with the Immune System

    Koch, Cody A. (et al.)

    Pages 49-67

  • The Role of NK Cells and T Cells in the Rejection of Embryonic Stem Cell-Derived Tissues

    Miyake, Bob (et al.)

    Pages 69-76

  • Mitigating the Risk of Immunogenicity in the Pursuit of Induced Pluripotency

    Fairchild, Paul J. (et al.)

    Pages 77-94

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-1-4614-5480-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-4614-5479-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4899-9932-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Immunological Barriers to Regenerative Medicine
Editors
  • Paul J. Fairchild
Series Title
Stem Cell Biology and Regenerative Medicine
Copyright
2013
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-5480-9
DOI
10.1007/978-1-4614-5480-9
Hardcover ISBN
978-1-4614-5479-3
Softcover ISBN
978-1-4899-9932-0
Series ISSN
2196-8985
Edition Number
1
Number of Pages
XIV, 334
Topics