Springer celebrates 175 years of publishing excellence! Join us >>

Advances in Experimental Medicine and Biology

Tandem Repeat Polymorphisms

Genetic Plasticity, Neural Diversity and Disease

Editors: Hannan, Anthony J. (Ed.)

  • Focuses on key aspects of TRPs in health and disease
  • Provides a detailed discussion of repeat sequences as mutable sites providing genetic variability upon which natural selection can act
  • Provides insights into how expanded polyalanine in specific proteins leads to developmental abnormalities and neurocognitive dysfunction
see more benefits

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-1-4614-5434-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4614-5433-5
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
About this book

This book addresses the role of tandem repeat polymorphisms (TRPs) in genetic plasticity, evolution, development, biological processes, neural diversity, brain function, dysfunction and disease. There are hundreds of thousands of unique tandem repeats in the human genome and their polymorphic distributions have the potential to greatly influence functional diversity and disease susceptibility. Recent discoveries in this expanding field are critically reviewed and discussed in a range of subsequent chapters, with a focus on the role of TRPs and their various gene products in evolution, development, diverse molecular and cellular processes, brain function and disease.

About the authors

ANTHO NY J. HANNAN is Head of the Neural Plasticity Laboratory, Florey Neuroscience Institutes and Associate Professor at the University of Melbourne, Parkville, Australia. Following undergraduate and PhD degrees at the University of Sydney, Anthony received postdoctoral neuroscience training at the University of Oxford, supported by a Nuffield Medical Fellowship. He currently holds an Australian Research Council (ARC) Future Fellowship (FT3) and an Honorary Senior Research Fellowship from the National Health and Medical Research Council (NHMRC). Main research interests include pathogenic mechanisms mediating Huntington’s disease and related tandem repeat expansion disorders, as well as other cognitive and psychiatric illnesses. In his laboratory, experimental models of gene‑environment interactions are used to explore experience‑dependent plasticity in the healthy and diseased brain.

Table of contents (12 chapters)

  • Tandem Repeat Polymorphisms

    Hannan, Anthony J.

    Pages 1-9

  • Evolution of Simple Sequence Repeats as Mutable Sites

    King, David G.

    Pages 10-25

  • Single Amino Acid and Trinucleotide Repeats

    Faux, Noel

    Pages 26-40

  • Promoter Microsatellites as Modulators of Human Gene Expression

    Sawaya, Sterling M. (et al.)

    Pages 41-54

  • Dynamic Mutations

    Eyk, Clare L. (et al.)

    Pages 55-77

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-1-4614-5434-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4614-5433-5
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Tandem Repeat Polymorphisms
Book Subtitle
Genetic Plasticity, Neural Diversity and Disease
Editors
  • Anthony J. Hannan
Series Title
Advances in Experimental Medicine and Biology
Series Volume
769
Copyright
2012
Publisher
Springer-Verlag New York
Copyright Holder
Landes Bioscience and Springer Science+Business Media New York
eBook ISBN
978-1-4614-5434-2
DOI
10.1007/978-1-4614-5434-2
Hardcover ISBN
978-1-4614-5433-5
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIX, 208
Topics