Advances in Experimental Medicine and Biology

TRIM/RBCC Proteins

Editors: Meroni, Germana (Ed.)

  • Gives an overview of state‑of‑the‑art basic findings on the tripartite motif (TRIM, also known as RBCC) family members
  • Discusses physiological and pathological roles of the TRIM
  • Provides the foundation to contribute to foster novel discoveries in the rapidly evolving field of TRIM proteins biology
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About this book

The genomic ‘golden age’ has delivered the sequence of numerous novel genes while leaving us with many unanswered questions about their function. This is particularly true for gene families as, often, members are annotated based on homology rather than function. The tripartite motif family belonged to this category, although, during the last few years, the field boosted an important wealth of biochemical, cellular and physiological breakthrough data. In the first part of this book, we attempt to offer an overview of state‑of‑the‑art basic findings on the tripartite motif (TRIM, also known as RBCC) family members and to deal in the second part with their relevant and growing physiological and pathological roles.

About the authors

Germana Meroni is a graduate of the University of Milan, Italy. She was a post‑graduate fellow at the Department of Biotechnology of the San Raffaele Hospital in Milan, Italy, and then post‑doctoral fellow at the Department of Human and Molecular Genetics of Baylor College of Medicine, Houston, TX (USA). She established her research group at the Telethon Institute of Genetics and Medicine (TIGEM) in Naples and then moved as leader of the Functional Genomics Laboratory at the Cluster in Biomedicine within AREA Science Park in Trieste, Italy. Her main research interest is the genetics and biochemistry of the Tripartite Motif family in health and disease.

Table of contents (10 chapters)

  • Genomics and Evolution of the TRIM Gene Family

    Meroni, Germana

    Pages 1-9

  • The Tripartite Motif

    Micale, Lucia (et al.)

    Pages 11-25

  • Trim Proteins as Ring Finger E3 Ubiquitin Ligases

    Ikeda, Kazuhiro (et al.)

    Pages 27-37

  • PML Nuclear Bodies and Other Trim-Defined Subcellular Compartments

    Batty, Elizabeth C. (et al.)

    Pages 39-58

  • TRIM Involvement in Transcriptional Regulation

    Cammas, Florence (et al.)

    Pages 59-76

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-1-4614-5398-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4614-5397-0
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
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Bibliographic Information

Bibliographic Information
Book Title
TRIM/RBCC Proteins
Editors
  • Germana Meroni
Series Title
Advances in Experimental Medicine and Biology
Series Volume
770
Copyright
2012
Publisher
Springer-Verlag New York
Copyright Holder
Landes Bioscience and Springer Science+Business Media New York
eBook ISBN
978-1-4614-5398-7
DOI
10.1007/978-1-4614-5398-7
Hardcover ISBN
978-1-4614-5397-0
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIX, 145
Topics