Advances in Biology and Therapy of Multiple Myeloma

Volume 2: Translational and Clinical Research

Editors: Munshi, Nikhil C., Anderson, Kenneth C. (Eds.)

  • Focuses on biology of MM especially, oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies
  • Explores all clinically important targets including those which have either therapeutic or prognostic significance
  • Provides perspective on new developments and information with emphasis both on basic science as well as its clinical impact
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eBook $169.00
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  • ISBN 978-1-4614-5260-7
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  • Immediate eBook download after purchase
Hardcover $219.00
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  • ISBN 978-1-4614-5259-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
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  • ISBN 978-1-4899-8914-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.

Table of contents (11 chapters)

  • T Cell Responses in Myeloma

    Brown, Ross (et al.)

    Pages 3-24

  • Novel Antigenic Targets for Immunotherapy in Myeloma

    Yi, Qing

    Pages 25-42

  • Antibody-Based Therapies in Multiple Myeloma

    Tai, Yu-Tzu

    Pages 43-71

  • Defining Multiple Myeloma as a Target for DNA Vaccines

    Sahota, Surinder S. (et al.)

    Pages 73-110

  • Harnessing Allogeneic Immunity for Anti-myeloma Response

    Bellucci, Roberto (et al.)

    Pages 111-129

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-1-4614-5260-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4614-5259-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-1-4899-8914-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Advances in Biology and Therapy of Multiple Myeloma
Book Subtitle
Volume 2: Translational and Clinical Research
Editors
  • Nikhil C. Munshi
  • Kenneth C. Anderson
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-5260-7
DOI
10.1007/978-1-4614-5260-7
Hardcover ISBN
978-1-4614-5259-1
Softcover ISBN
978-1-4899-8914-7
Edition Number
1
Number of Pages
X, 290
Topics