Advances in Experimental Medicine and Biology

DNA Helicases and DNA Motor Proteins

Editors: Spies, Maria (Ed.)

  • Provides first systematic overview of structure, function and regulation of DNA helicases
  • Integrates knowledge obtained through diverse technical approaches
  • Gives a unified view on how helicases function in the cell and are regulated in response to different cellular stresses
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eBook $189.00
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  • ISBN 978-1-4614-5037-5
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Hardcover $249.00
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  • ISBN 978-1-4614-5036-8
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Softcover $249.00
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  • ISBN 978-1-4899-9851-4
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About this book

In recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA and/or remodels nucleoprotein complexes, however, remain to be answered. It is even less understood how the helicase motors are incorporated into a wide range of genome maintenance and repair machines.

The field has reached a stage when the studies of molecular mechanisms and basic biology of helicases can and shall be integrated with the studies of development, cancer and longevity. The objective of this book is to provide the first systematic overview of structure, function and regulation of DNA helicases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studies the editors aim to provide a unified view on how helicases function in the cell, are regulated in response to different cellular stresses and are integrated into large macromolecular assemblies to form a complex and adaptive living system.

Table of contents (14 chapters)

  • Overview: What Are Helicases?

    Wu, Colin G. (et al.)

    Pages 1-16

  • Structure and Mechanisms of SF1 DNA Helicases

    Raney, Kevin D. (et al.)

    Pages 17-46

  • Structure and Mechanisms of SF2 DNA Helicases

    Beyer, David C. (et al.)

    Pages 47-73

  • Structure and Mechanism of Hexameric Helicases

    Medagli, Barbara (et al.)

    Pages 75-95

  • Helicases at the Replication Fork

    McGlynn, Peter

    Pages 97-121

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-4614-5037-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.00
price for USA
  • ISBN 978-1-4614-5036-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.00
price for USA
  • ISBN 978-1-4899-9851-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
DNA Helicases and DNA Motor Proteins
Editors
  • Maria Spies
Series Title
Advances in Experimental Medicine and Biology
Series Volume
973
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-5037-5
DOI
10.1007/978-1-4614-5037-5
Hardcover ISBN
978-1-4614-5036-8
Softcover ISBN
978-1-4899-9851-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XII, 304
Topics