Role of the Transcriptome in Breast Cancer Prevention

Authors: Russo, Jose, Russo, Irma H.

  • Provides new insight on cancer prevention based on meticulously researched processed that have been gleaned from basic to translational research with a direct clinical application
  • Targeted to the medical profession and those interested in biomedical research
  • Outlines a model to the basic researchers and for those that are aiming to apply their work in the future to the clinic
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eBook $189.00
price for USA (gross)
  • ISBN 978-1-4614-4884-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.00
price for USA
  • ISBN 978-1-4614-4883-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.00
price for USA
  • ISBN 978-1-4899-8993-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book will provide the latest advances in molecular and cellular biology for establishing the foundation of a complete understanding of the mechanisms of breast differentiation leading to cancer prevention. The authors are based on the epidemiological evidence indicating that early first full term pregnancy is a protective factor in human against breast cancer and they have used this paradigm and developed experimental systems in both in vivo and in vitro that have demonstrated mechanistically how the differentiation at the organ and cellular level takes place. This knowledge has provided the blueprint for developing better understanding of the basis of cancer prevention. The transcriptoma analysis of the breast of pre and post-menopausal women has established a genomic signature imprinted in the breast that differs according to the reproductive history of the woman showing that early first full term pregnancy reprogram the organ. This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non coding RNA sequences and posttranscriptional control driven by the splicesome. The plasticity of the genome of the human breast make possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones that mimic pregnancy without pregnancy. The author have established the basis of clinical trials for prevention and the discovery that short 15aa peptides of the chorionic gonadotropin hormone can be used in human breast cancer prevention based on preclinical and clinical data.

Table of contents (10 chapters)

  • The Epidemiology of Breast Cancer and the Basis for Prevention

    Russo, Jose (et al.)

    Pages 1-27

  • An In Vivo Model of Breast Cancer Prevention

    Russo, Jose (et al.)

    Pages 29-71

  • Comparative Effects of the Preventive Effect of Pregnancy, Steroidal Hormones, and hCG in the Transcriptomic Profile of the Rat Mammary Gland

    Russo, Jose (et al.)

    Pages 73-189

  • The Use of In Vitro Three-Dimensional System for Studying Breast Cancer and Preventing Agents

    Russo, Jose (et al.)

    Pages 191-241

  • Methodological Approach for Studying the Human Breast

    Russo, Jose (et al.)

    Pages 243-268

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-4614-4884-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.00
price for USA
  • ISBN 978-1-4614-4883-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.00
price for USA
  • ISBN 978-1-4899-8993-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Role of the Transcriptome in Breast Cancer Prevention
Authors
Copyright
2013
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-4884-6
DOI
10.1007/978-1-4614-4884-6
Hardcover ISBN
978-1-4614-4883-9
Softcover ISBN
978-1-4899-8993-2
Edition Number
1
Number of Pages
XIV, 454
Topics