Advances in Experimental Medicine and Biology

Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications

Proceedings of the 6th International Conference on Sodium Calcium Exchange

Editors: Annunziato, Lucio (Ed.)

  • Based on the 6th International Conference on Sodium Calcium Exchange
  • Includes information from internationally-known experts on sodium calcium exchange
  • Incorporates recent advances in research
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eBook $189.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-1-4614-4756-6
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  • Included format: EPUB, PDF
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Hardcover $249.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4614-4755-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4899-7821-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book reports the text of the lectures of the 6th International Conference on Sodium Calcium Exchange held in Lacco Ameno in the Island of Ischia in the Gulf of Naples, Italy, from October 1 to October 5, 2011.

The present book uncovers the most striking new findings on NCX that emerged since the previous Conference on Sodium Calcium Exchange, such as the structural dissection of the molecular determinants of Ca2+ sensitivity of the exchanger, the epigenetic regulation of ncx1 gene, the molecular identification of the mitochondrial Sodium Calcium Exchanger, and the discovery of NCX in unexpected anatomical locations such as the female reproductive tract.

The book is organized into 11 parts covering NCX structural aspects, genetic and epigenetic regulation, regulatory mechanisms, subcellular localization in mitochondria, involvement in neurodegenerative diseases and in immune regulation, and the role of the cardiovascular and endocrine systems, as well as diabetes in physiology and pathophysiology. Selected chapters of the book are also devoted to the interaction of NCKX and other ion channels and transporters with NCX, like ASICs, TRPM, and NHE.

About the authors

Lucio Annunziato is Professor of Pharmacology and chairman of the Department of Neuroscience in the School of Medicine at the “Federico II” University of Naples, Italy. He is coordinator of the University’s Neuroscience Ph.D. program. He is also past-president of the Italian Society for Neuroscience. Dr. Annunziato has authored more that 190 full papers in peer reviewed international journals in the field of neuroscience and molecular pharmacology of plasmamembrane transporters and ionic channels involved in the pathophysiology of stroke and other neurodegenerative diseases. 

Reviews

From the reviews:

“It collects in one place state-of-the-art information on all facets of the structure and function of sodium calcium exchangers in biological systems with a special focus on pathophysiological implications. … This will be of most value to research scientists, including students, whose research involves studying the mechanisms for maintaining ion homeostasis in biological systems. … I highly recommend it to all researchers who work in the field of ion homeostasis.” (Thomas L. Pazdernik, Doody's Book Reviews, March, 2013)

Table of contents (38 chapters)

  • Livin’ with NCX and Lovin’ It: A 45 Year Romance

    Blaustein, Mordecai P.

    Pages 3-15

  • 20 Years from NCX Purification and Cloning: Milestones

    Nicoll, Debora A. (et al.)

    Pages 17-23

  • Ca2+ Regulation in the Na+/Ca2+ Exchanger Features a Dual Electrostatic Switch Mechanism

    Hilge, Mark

    Pages 27-33

  • Molecular Determinants of Allosteric Regulation in NCX Proteins

    Giladi, Moshe (et al.)

    Pages 35-48

  • NCX1: Mechanism of Transport

    Ottolia, Michela (et al.)

    Pages 49-54

Buy this book

eBook $189.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-1-4614-4756-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4614-4755-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4899-7821-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications
Book Subtitle
Proceedings of the 6th International Conference on Sodium Calcium Exchange
Editors
  • Lucio Annunziato
Series Title
Advances in Experimental Medicine and Biology
Series Volume
961
Copyright
2013
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-4756-6
DOI
10.1007/978-1-4614-4756-6
Hardcover ISBN
978-1-4614-4755-9
Softcover ISBN
978-1-4899-7821-9
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XXIV, 463
Topics