Advances in Delivery Science and Technology

RNA Interference from Biology to Therapeutics

Editors: Howard, Kenneth A. (Ed.)

  • Addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches
  • Covers RNAi therapeutic design to optimize siRNA potency and reduce off-target effects
  • Discusses current delivery technologies to overcome both intracellular and extracellular barriers
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eBook $219.00
price for USA (gross)
  • ISBN 978-1-4614-4744-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA
  • ISBN 978-1-4614-4743-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.00
price for USA
  • ISBN 978-1-4899-9319-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The enormous potential of siRNA as a therapeutic has led to an explosion of interest from the scientific community. There has been intense interest from Big Pharma to capitalise on this new technology but the fact remains that delivery is a key determinant in realizing the full clinical potential of RNA interference. There is an urgent need for better delivery methods to take this technology forward. This book addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. This book will cover RNAi therapeutic design to optimize siRNA potency and reduce off-target effects and current delivery technologies to overcome both intracellular and extracellular barriers. The reader will gain an insight into RNA interference from the cellular mechanisms to screening to siRNA design right through to diagnostic and therapeutic applications.

About the authors

Kenneth Alan Howard is an Associate Professor and Group Leader at the Department of Molecular Biology at the Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Denmark. His team is based in a highly interdisciplinary setting with research and teaching activities focused on advanced drug delivery, nanomedicine, RNA interference, and inflammation. Dr Howard is CEO of an Aarhus University spin-out company that provides delivery solutions for RNA interference-based therapeutics. Kenneth Alan Howard received a PhD in Pharmaceutical Science from the University of Nottingham, UK in 1995, and has held postdoctoral positions at the CRC Institute for Cancer Studies, University of Birmingham, UK and the School of Pharmacy, University of London. Dr Howard is an active member of the Controlled Release Society serving on the Board of Scientific Advisors (chair), Nominations Committee and organizer of a CRS Educational workshop “RNA Interference Biology and Therapeutics”.   

Table of contents (15 chapters)

  • RNA Interference Pathways and Therapeutic Exploitation

    Bramsen, Jesper B. (et al.)

    Pages 1-29

  • Synthetic Dicer-Substrate siRNAs as Triggers of RNA Interference

    Rose, Scott D. (et al.)

    Pages 31-56

  • The Role of MicroRNAs in Natural Tissue Development and Application in Regenerative Medicine

    Andersen, Morten Østergaard (et al.)

    Pages 57-78

  • Intracellular Delivery Considerations for RNAi Therapeutics

    Zhu, Yu (et al.)

    Pages 79-95

  • Mucosal Delivery of RNAi Therapeutics

    González, Borja Ballarín (et al.)

    Pages 97-125

Buy this book

eBook $219.00
price for USA (gross)
  • ISBN 978-1-4614-4744-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA
  • ISBN 978-1-4614-4743-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.00
price for USA
  • ISBN 978-1-4899-9319-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
RNA Interference from Biology to Therapeutics
Editors
  • Kenneth A. Howard
Series Title
Advances in Delivery Science and Technology
Copyright
2013
Publisher
Springer US
Copyright Holder
Controlled Release Society
eBook ISBN
978-1-4614-4744-3
DOI
10.1007/978-1-4614-4744-3
Hardcover ISBN
978-1-4614-4743-6
Softcover ISBN
978-1-4899-9319-9
Series ISSN
2192-6204
Edition Number
1
Number of Pages
XVI, 340
Topics