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Advances in DNA Repair in Cancer Therapy

  • Book
  • © 2013

Overview

Editors:
  1. Lawrence Panasci

    1. Jewish General Hospital, Montreal, Canada

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  2. Raquel Aloyz

    1. , Department of Oncology, McGill University, Montreal, Canada

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    You can also search for this editor in PubMed   Google Scholar

  3. Moulay Alaoui-Jamali

    1. McGill University, Department of Medicine and Oncology, Faculty of Medicine, Montreal, Canada

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    You can also search for this editor in PubMed   Google Scholar

  • Reveals the latest developments in DNA repair in cancer therapy and the latest progress in research
  • Discusses novel DNA repair enzymes such as PARP and DNA-PK
  • Appeals to cancer researchers as well as oncologists

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-viii
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  2. Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs

    • Anderson T. Wang, Peter J. McHugh, John A. Hartley
    Pages 1-23

  3. DNA-PK, a Pharmacological Target in Cancer Chemotherapy and Radiotherapy?

    • Bernard Salles, Patrick Calsou, Gladys Mirey
    Pages 25-44

  4. Growth Factor Receptor Signaling, DNA Damage Response, and Cancer Cell Susceptibility to Chemotherapy and Relapses

    • Moulay Alaoui-Jamali, Amine Saad, Gerald Batist
    Pages 45-74

  5. The Relationship Between DNA-Repair Genes, Cellular Radiosensitivity, and the Response of Tumors and Normal Tissues to Radiotherapy

    • David Murray, Matthew Parliament
    Pages 75-128

  6. Important Roles of ERCC1 in DNA Repair and Targeted Therapy

    • Jennifer J. Hu, Joseph de la Garza, Sathish K. Srinivasan, Ann Alyssa Kurian, Feng Gong
    Pages 129-142

  7. The Role of BRCA1 and BRCA2 in Anticancer Drug Therapy

    • Andrew Y. Shuen, Jorge S. Reis-Filho, William D. Foulkes
    Pages 143-155

  8. DNA-PK in CLL Chemotherapy

    • L. Amrein, D. Davidson, R. Aloyz, L. Panasci
    Pages 157-166

  9. Poly(ADP) Ribose Polymerase at the Interface of DNA Damage Signaling and DNA Repair

    • Jana Krietsch, Michèle Rouleau, Michel Lebel, Guy Poirier, Jean-Yves Masson
    Pages 167-186

  10. Cellular Protection Against the Antitumor Drug Bleomycin

    • Dindial Ramotar, Mustapha Aouida
    Pages 187-209

  11. ATR as a Therapeutic Target

    • Fiona K. Middleton, Nicola J. Curtin
    Pages 211-228

  12. Telomeres, Telomerase, and DNA Damage Response in Cancer Therapy

    • Raina A. Tamakawa, Helen B. Fleisig, Judy M. Y. Wong
    Pages 229-279

  13. RAD51 Is a Key Protein of DNA Repair and Homologous Recombination in Humans

    • Alexander V. Mazin, Olga M. Mazina
    Pages 281-302

  14. Back Matter

    Pages 303-312
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Keywords

About this book

​A comprehensive review of the recent developments in DNA repair research that have potential for translational applications. The book explains in detail the various biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK. The book captures-for both cancer researchers and oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.​

Editors and Affiliations

  • Jewish General Hospital, Montreal, Canada

    Lawrence Panasci

  • , Department of Oncology, McGill University, Montreal, Canada

    Raquel Aloyz

  • McGill University, Department of Medicine and Oncology, Faculty of Medicine, Montreal, Canada

    Moulay Alaoui-Jamali

Bibliographic Information

  • Book Title: Advances in DNA Repair in Cancer Therapy

  • Editors: Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-4614-4741-2

  • Publisher: Humana New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2013

  • Hardcover ISBN: 978-1-4614-4740-5Published: 06 December 2012

  • Softcover ISBN: 978-1-4899-9308-3Published: 28 January 2015

  • eBook ISBN: 978-1-4614-4741-2Published: 09 December 2012

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: VIII, 312

  • Topics: Cancer Research, Molecular Medicine

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