Genetic and Molecular Epidemiology of Multiple Myeloma

Editors: Lentzsch, Suzanne (Ed.)

  • Explores the role of protein translation in multiple myeloma
  • Discusses epigenetic gene silencing as a new target for multiple myeloma immune surveillance
  • Examines the cell cycle control of plasma cell differentiation
see more benefits

Buy this book

eBook $149.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-1-4614-4660-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4614-4659-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4899-9865-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Multiple myeloma is a plasma cell malignancy characterized by complex heterogenous cytogenetic abnormalities that accounts for 1.4% of all cancers, and approximately 10% of hematologic malignancies. The clinical manifestations of multiple myeloma include lytic bone lesions, cytopenia, hypercalcemia, renal dysfunction, hyperviscosity of the blood, immunodeficiency, and peripheral neuropathy. Based on the clinical and genetic data, probably all cases of multiple myeloma arise from an asymptomatic monoclonal gammopathy of unknown significance. The exact mechanism of the transition from MGUS to overt multiple myeloma is still not well understood. Recent oncogenomic studies have further advanced our understanding of the molecular pathogenesis of multiple myeloma. This book will give a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this disease.

Table of contents (6 chapters)

  • Genetics of Multiple Myeloma

    Schuster, Steven (et al.)

    Pages 1-16

  • Gene Expression Signature in MGUS and Multiple Myeloma

    Heuck, Christoph J. (et al.)

    Pages 17-41

  • Cap-Dependent Protein Translation Initiation in Multiple Myeloma: An Attractive Target for Therapy

    Li, Shirong (et al.)

    Pages 43-57

  • IRES-Dependent, Cap-Independent Translation in Multiple Myeloma

    Gera, Joseph (et al.)

    Pages 59-76

  • The Role of Notch Signaling in Multiple Myeloma

    Xu, Dehui (et al.)

    Pages 77-95

Buy this book

eBook $149.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-1-4614-4660-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4614-4659-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4899-9865-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Genetic and Molecular Epidemiology of Multiple Myeloma
Editors
  • Suzanne Lentzsch
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-4660-6
DOI
10.1007/978-1-4614-4660-6
Hardcover ISBN
978-1-4614-4659-0
Softcover ISBN
978-1-4899-9865-1
Edition Number
1
Number of Pages
VII, 125
Topics