Natural Products and Cancer Drug Discovery

1. Front Matter

   Pages i-xii

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2. Natural Product Drugs and Cancer Therapeutics

   1. Front Matter

      Pages 1-1

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   2. The Impact of Natural Products Upon Cancer Chemotherapy

      • A. Ganesan

      Pages 3-15

   3. Identification and Development of Vascular Disrupting Agents: Natural Products That Interfere with Tumor Growth

      • Andrea T. Hooper, Frank Loganzo, Chad May, Hans-Peter Gerber

      Pages 17-38

   4. Discodermolide: Past, Present, and Future

      • Ross E. Longley

      Pages 39-58

   5. HDAC Inhibitors and Other Histone Modifying Natural Products as Emerging Anticancer Agents

      • Lilibeth A. Salvador, Hendrik Luesch

      Pages 59-95

   6. Natural Product Cytotoxins as Payloads for Antibody Drug Conjugates

      • Frank E. Koehn

      Pages 97-119

3. Advances in Natural Product Cancer Drug Discovery

   1. Front Matter

      Pages 121-121

      PDF

   2. Natural Product Scaffolds in Cancer Therapy

      • Christian P. Mang, Lars Ole Haustedt

      Pages 123-173

   3. The Role of Genetic Engineering in Natural Product-Based Anticancer Drug Discovery

      • Claudia Eva-Maria Unsin, Scott R. Rajski, Ben Shen

      Pages 175-191

   4. Accessing Anti-cancer Natural Products by Plant Cell Culture

      • Lisa M. Leone, Susan C. Roberts

      Pages 193-211

   5. Natural Products as Tools for Discovering New Cancer Targets

      • John A. Beutler

      Pages 213-237

4. Back Matter

   Pages 239-244

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This volume will cover the natural products as they relate to cancer chemotherapy. The topics will include history and current status , recent launches, new clinical candidates and approved drugs directly derived from natural products, current and future cancer target opportunities for natural products, leveraging natural products as tools for new target generation , new approaches to cancer drug discovery through natural products based lead generation, and enabling technologies which leverage the unique attributes of natural products.

• HDAC inhibitors
• Natural Products and Cancer Drug Discovery
• cancer therapeutics
• discodermolide
• natural product cytotoxins

From the reviews:

“This book covers a range of topics related to drug discovery, natural product chemistry, cancer biology, and chemical biology. … value to researchers in both academia and the pharmaceutical industry who are involved in the study and development of natural products as potential chemotherapeutic agents. It also will be helpful to basic biomedical scientists and clinicians as a quick overview of this area of research and its recent developments. … also provides a critical assessment of the challenges that researchers in this research field face.” (Bao Ting Zhu, Doody’s Review Service, March, 2013)

• , Natural Products/World Wide Medicinal Ch, Pfizer Inc, Groton, USA

  Frank E. Koehn

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