Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems

Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems

Authors: Thiriet, Marc

  • Reviews signaling pathways in the regulation of circulatory and respiratory function
  • Describes ion and molecular carriers and receptors
  • Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows
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About this book

The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning.

Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors.  Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled.  Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction.

Table of contents (12 chapters)

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-4614-4370-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-4614-4369-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems
Authors
Series Title
Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems
Series Volume
4
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-4370-4
DOI
10.1007/978-1-4614-4370-4
Hardcover ISBN
978-1-4614-4369-8
Series ISSN
2193-1682
Edition Number
1
Number of Pages
XV, 1064
Topics