Editors:
- Organized to mimic biotherapeutic product lifecycle
- Focuses on the applications of biophysics to different disciplines; in particular, focusing on protein therapeutic development
- First fully comprehensive book to cover protein aggregation and the biophysical techniques used in the development lifecycle of biopharmaceuticals
- Includes supplementary material: sn.pub/extras
Part of the book series: Biophysics for the Life Sciences (BIOPHYS, volume 4)
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Table of contents (11 chapters)
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Front Matter
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Back Matter
About this book
This book can be used to provide insight into this important application of biophysics for those who are planning a career in protein therapeutic development, and for those outside this area who are interested in understanding it better. The initial chapters describe the underlying theory, and strengths and weaknesses of the different techniques commonly used during therapeutic development. The majority of the chapters discuss the applications of these techniques, including case studies, across the product lifecycle from early discovery, where the focus is on identifying targets, and screening for potential drug product candidates, through expression and purification, large scale production, formulation development, lot-to-lot comparability studies, and commercial support including investigations.
Editors and Affiliations
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, Research & Development, Amgen, Inc., Thousand Oaks, USA
Linda O. Narhi
Bibliographic Information
Book Title: Biophysics for Therapeutic Protein Development
Editors: Linda O. Narhi
Series Title: Biophysics for the Life Sciences
DOI: https://doi.org/10.1007/978-1-4614-4316-2
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media New York 2013
Hardcover ISBN: 978-1-4614-4315-5Published: 23 February 2013
Softcover ISBN: 978-1-4899-9246-8Published: 06 March 2015
eBook ISBN: 978-1-4614-4316-2Published: 26 February 2013
Edition Number: 1
Number of Pages: IX, 293
Number of Illustrations: 42 b/w illustrations, 31 illustrations in colour
Topics: Pharmacology/Toxicology, Medical Biochemistry, Protein Science, Protein-Ligand Interactions, Biological and Medical Physics, Biophysics