Biophysics for the Life Sciences

Biophysics for Therapeutic Protein Development

Editors: Narhi, Linda O. (Ed.)

  • Organized to mimic biotherapeutic product lifecycle
  • Focuses on the applications of biophysics to different disciplines; in particular, focusing on protein therapeutic development
  • First fully comprehensive book to cover protein aggregation and the biophysical techniques used in the development lifecycle of biopharmaceuticals
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eBook $159.00
price for USA (gross)
  • ISBN 978-1-4614-4316-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-4614-4315-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book can be used to provide insight into this important application of biophysics for those who are planning a career in protein therapeutic development, and for those outside this area who are interested in understanding it better. The initial chapters describe the underlying theory, and strengths and weaknesses of the different techniques commonly used during therapeutic development. The majority of the chapters discuss the applications of these techniques, including case studies, across the product lifecycle from early discovery, where the focus is on identifying targets, and screening for potential drug product candidates, through expression and purification, large scale production, formulation development, lot-to-lot comparability studies, and commercial support including investigations.

Table of contents (11 chapters)

  • Introduction

    Narhi, Linda O.

    Pages 1-5

  • High-Throughput Biophysical Approaches to Therapeutic Protein Development

    He, Feng (et al.)

    Pages 7-31

  • Techniques for Higher-Order Structure Determination

    Kranz, James (et al.)

    Pages 33-82

  • Biophysical Techniques for Protein Size Distribution Analysis

    Wei, Ziping (et al.)

    Pages 83-97

  • Qualification of Biophysical Methods for the Analysis of Protein Therapeutics

    Jiang, Yijia (et al.)

    Pages 99-126

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-1-4614-4316-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-4614-4315-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Biophysics for Therapeutic Protein Development
Editors
  • Linda O. Narhi
Series Title
Biophysics for the Life Sciences
Series Volume
4
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-4316-2
DOI
10.1007/978-1-4614-4316-2
Hardcover ISBN
978-1-4614-4315-5
Edition Number
1
Number of Pages
IX, 293
Number of Illustrations and Tables
42 b/w illustrations, 31 illustrations in colour
Topics