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  • © 2013

Biophysical approaches to translational control of gene expression

  • Consists of up-to-date and comprehensive reviews of research and relevant new imaging and structural approaches
  • Addresses major advances in researching cell’s molecular machinery through analytical, computational, and imaging methods
  • Focuses on developing biophysical approaches to studying control of gene expression at the translational level

Part of the book series: Biophysics for the Life Sciences (BIOPHYS, volume 1)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xii
  2. X-Ray Analysis of Prokaryotic and Eukaryotic Ribosomes

    • Lasse B. Jenner, Adam Ben-Shem, Natalia Demeshkina, Marat Yusupov, Gulnara Yusupova
    Pages 1-25
  3. A Passage Through the Ribosome by Cryo-EM

    • Partha P. Datta, Ananya Chatterjee
    Pages 27-50
  4. Molecular Dynamics Simulations of the Ribosome

    • Karissa Y. Sanbonmatsu, Scott C. Blanchard, Paul C. Whitford
    Pages 51-68
  5. Structural Analyses of the Ribosome by Chemical Modification Methods

    • Jonathan A. Leshin, Arturas Meskauskas, Jonathan D. Dinman
    Pages 69-81
  6. Riboproteomic Approaches to Understanding IRES Elements

    • Encarnacion Martinez-Salas, David Piñeiro, Noemi Fernandez
    Pages 103-118
  7. Rapid Kinetic Analysis of Protein Synthesis

    • Marina V. Rodnina, Wolfgang Wintermeyer
    Pages 119-139
  8. Investigating RNAs Involved in Translational Control by NMR and SAXS

    • Kathryn D. Mouzakis, Jordan E. Burke, Samuel E. Butcher
    Pages 141-172
  9. Analyses of RNA–Ligand Interactions by Fluorescence Anisotropy

    • Aparna Kishor, Gary Brewer, Gerald M. Wilson
    Pages 173-198
  10. A Multidisciplinary Approach to RNA Localisation

    • Russell S. Hamilton, Graeme Ball, Ilan Davis
    Pages 213-233
  11. Virtual Screening for RNA-Interacting Small Molecules

    • Hyun-Ju Park, So-Jung Park
    Pages 235-252
  12. Translational Control of Synaptic Plasticity and Memory

    • Arkady Khoutorsky, Christos Gkogkas, Nahum Sonenberg
    Pages 289-310
  13. Back Matter

    Pages 311-317

About this book

This book provides a premier resource on understanding the ribosome's essential nature and how it interacts with other proteins and nucleic acids to control protein synthesis. As one of the central foundations in our understanding of the biology at the molecular level, this topic appeals to a wide audience, from bench researcher to clinician.  With the advent of atomic scale structures, methods to visualize and separate individual molecules, and the computational power to model the complex interactions of over a million atoms at once, our understanding of how gene expression is controlled at the level of protein translation is now deeply ensconced in the biophysical realm.

Editors and Affiliations

  • College Park, Cell Biology and Molecular Genetics, University of Maryland, College Park, USA

    Jonathan D. Dinman

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access