Mitochondrial Disorders Caused by Nuclear Genes

Editors: Wong, Lee-Jun C. (Ed.)

  • Covers recognizable syndromes and heterogeneous mitochondrial disease caused by specific genes
  • Readers will learn biochemical, molecular, clinical, and genetic aspects of the complex dual genome mitochondrial disorders
  • Examines different organs effected by mitochondrial disorder
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eBook $189.00
price for USA (gross)
  • ISBN 978-1-4614-3722-2
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  • Immediate eBook download after purchase
Hardcover $249.00
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  • ISBN 978-1-4614-3721-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.00
price for USA
  • ISBN 978-1-4899-9241-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Mitochondrial cytopathies are mutations in the inherited maternal mitochondrial genome, or the nuclear DNA-mutation. Mitochondrial respiratory chain disorders (RCD) are a group of genetically and clinically heterogeneous diseases, due to the fact that protein components of the respiratory chain are encoded by both mitochondrial and nuclear genomes and are essential in all cells.  In addition, the biogenesis, structure and function of mitochondria, including DNA replication, transcription, and translation, all require nuclear encoded genes.  Since mitochondria are present in every cell, every tissue, mitochondrial disorder usually affects multiple organs.

Table of contents (21 chapters)

  • The Clinical Spectrum of Nuclear DNA-Related Mitochondrial Disorders

    DiMauro, Salvatore (et al.)

    Pages 3-25

  • Biochemical and Molecular Methods for the Study of Mitochondrial Disorders

    Wong, Lee-Jun C.

    Pages 27-45

  • Mitochondrial Disorders Associated with the Mitochondrial DNA Polymerase g: A Focus on Intersubunit Interactions

    Young, Matthew J. (et al.)

    Pages 49-72

  • Alpers–Huttenlocher Syndrome, Polymerase Gamma 1, and Mitochondrial Disease

    Saneto, Russell P. (et al.)

    Pages 73-89

  • Deoxyguanosine Kinase

    Dimmock, David Paul

    Pages 91-102

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-4614-3722-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.00
price for USA
  • ISBN 978-1-4614-3721-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.00
price for USA
  • ISBN 978-1-4899-9241-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mitochondrial Disorders Caused by Nuclear Genes
Editors
  • Lee-Jun C. Wong
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4614-3722-2
DOI
10.1007/978-1-4614-3722-2
Hardcover ISBN
978-1-4614-3721-5
Softcover ISBN
978-1-4899-9241-3
Edition Number
1
Number of Pages
XII, 372
Topics