Advances in Neurobiology

Brain Immune System Signal Molecules in Protection from Aerobic and Anaerobic Infections

Authors: Galoyan, Armen A.

  • Written by a pioneer of the specialized field of neuroimmunology
  • Presents a full overview of the neuroimmune system
  • Useful to academics, researchers, and PhD students in neuroscience and neurobiology
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  • ISBN 978-1-4614-3667-6
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Hardcover $259.00
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  • ISBN 978-1-4614-3666-9
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  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
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  • ISBN 978-1-4899-8815-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Proline-rich polypeptides - in particular (PRP-1) galarmin and its structural analogues – are, when isolated from the neurosecretory granules of neurohypophysis of humans and animals, a new type of hypothalamic peptides. They work against aerobic, anaerobic, gram-positive, and gram-negative microorganisms in vivo, and do not have etiotropic properties. They are unique and capable substitutes to antibiotics, and, moreover, may be effective against strains, such as MRSA, that develop resistance to antibiotics. Galarmin, a component of the brain neuroendocrine system produced by the neurosecretory cells of hypothalamus, possesses  immunomodulative, neuroprotective, antioxidant, antitumorigenic and hematopoietic properties. Moreover, galarmin and its structural analogues are powerful anti-inflammatory  compounds. 

In addition to presenting a full overview of the neuroimmune system, it emphasizes the antibacterial, neuroprotective, and neuroregenerative properties of proline-rich polypeptides.  It investigates the mechanism of galarmin’s action during different infectious processes, where it targets such dangerous pathogens as  Bacillus anthracis, Clostridium perfringens, Mycobacterium tuberculosis, and Methycillin resistant Staphylococcus aureus.   This research is important from both a theoretical and a clinical point of view, creating new prospects for the modern pharmaceutical industry and neuroendocrine, neuroimmunological sciences.

Dr. Galoyan is a pioneer of the specialized field of neuroimmunology. During his 45-year long career, he has discovered a neuroendocrine immune system of the brain and identified a new type of brain cytokines: proline-rich polypeptides. The most important of these, PRP-1 (galarmin) has been shown to possess antibacterial properties and protect from certain neurotoxins.

Table of contents (12 chapters)

  • The Cytokine System

    Galoyan, Armen A.

    Pages 1-13

  • The Discovery of the Brain Immunomodulators

    Galoyan, Armen A.

    Pages 15-23

  • Brain Neuroendocrine Immune System: Neurosecretion of Interleukins and New Cytokines Produced by NSO and NPV of Hypothalamus

    Galoyan, Armen A.

    Pages 25-39

  • Antibacterial and Antiviral Activity of PRP-1 (Galarmin) and Some Immunological Mechanisms of its Action

    Galoyan, Armen A.

    Pages 41-55

  • Treatment and Prophylaxis of Anthrax by Galarmin: Receptor Tyrosine Kinases is a Target of Galarmin

    Galoyan, Armen A.

    Pages 57-74

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-1-4614-3667-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-1-4614-3666-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4899-8815-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Brain Immune System Signal Molecules in Protection from Aerobic and Anaerobic Infections
Authors
Series Title
Advances in Neurobiology
Series Volume
6
Copyright
2012
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-3667-6
DOI
10.1007/978-1-4614-3667-6
Hardcover ISBN
978-1-4614-3666-9
Softcover ISBN
978-1-4899-8815-7
Series ISSN
2190-5215
Edition Number
1
Number of Pages
XVI, 200
Topics