Patho-Epigenetics of Disease

Editors: Minarovits, Janos, Niller, Hans Helmut (Eds.)

  • Patho-Epigenetics is a new discipline, and  it’s covered here in detail
  • Written by experts in this exciting new field
  • Brings together recent results of epigenetic research with special attention to disease development
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eBook $189.00
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  • ISBN 978-1-4614-3345-3
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Hardcover $249.00
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  • ISBN 978-1-4614-3344-6
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Softcover $249.00
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  • ISBN 978-1-4899-9178-2
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About this book

In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences.

Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to “remember” their proper cellular identity.

An alternative system of epigenetic memory, the Polycomb and Trithorax groups of protein complexes, that may operate both independently from and in concert with DNA methylation, ensures the heritable regulation of gene expression via modification of histone tails.

The complex interplay of epigenetic regulatory mechanisms permits both the dynamic modulation of gene expression and the faithful transmission of gene expression patterns to each progeny cell upon division. These carefully orchestrated processes can go wrong, however, resulting in epigenetic reprogramming of the cells that may manifest in pathological changes, as it was first realized during the studies of epigenetic alterations in malignant tumors. By now it became a well established fact that not only genetic changes, but also the disruption of epigenetic regulation can result in carcinogenesis and tumor progression. Scientists working in other fields soon followed the pioneering work of cancer researchers, and revealed that epigenetic dysregulation forms the basis of a wide spectrum of human diseases.

Table of contents (14 chapters)

  • The Impact of Foreign DNA Integration on Tumor Biology and Evolution via Epigenetic Alterations

    Doerfler, Walter

    Pages 1-14

  • The Role of DNMT3B Mutations in the Pathogenesis of ICF Syndrome

    Gatto, Sole (et al.)

    Pages 15-41

  • Dysfunction of the Methyl-CpG-Binding Protein MeCP2 in Rett Syndrome

    Calfa, Gaston (et al.)

    Pages 43-69

  • Epigenetic Alterations in Glioblastoma Multiforme

    Wiencke, John K.

    Pages 71-90

  • Aberrant Epigenetic Regulation in Breast Cancer

    Toland, Amanda Ewart

    Pages 91-122

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-4614-3345-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.00
price for USA
  • ISBN 978-1-4614-3344-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.00
price for USA
  • ISBN 978-1-4899-9178-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Patho-Epigenetics of Disease
Editors
  • Janos Minarovits
  • Hans Helmut Niller
Copyright
2012
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-3345-3
DOI
10.1007/978-1-4614-3345-3
Hardcover ISBN
978-1-4614-3344-6
Softcover ISBN
978-1-4899-9178-2
Edition Number
1
Number of Pages
XIV, 466
Topics