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Molecular Determinants of Radiation Response

  • Book
  • © 2011

Overview

Editors:
  1. Theodore L. DeWeese

    1. Dept. Radiation Oncology, Johns Hopkins University, Baltimore, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Marikki Laiho

    1. Dept. Radiation Oncology, Johns Hopkins University, Baltimore, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins
  • Presents comprehensive discussions on where and how specific alterations in function of these pathways and proteins result in substantive modifications of cellular response to DNA injury
  • A timely and relevant text for basic and translational researchers
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Cancer Research (CUCR)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Molecular Basis of the DNA Damage Responses

    1. Front Matter

      Pages 1-1
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    2. H2AX in DNA Damage Response

      • Christophe E. Redon, Jennifer S. Dickey, Asako J. Nakamura, Olga A. Martin, William M. Bonner
      Pages 3-33

    3. DNA Damage Signaling Downstream of ATM

      • Fred Bunz
      Pages 35-52

    4. Checkpoint Control Following Radiation Exposure

      • Markus Lobrich, Aaron A. Goodarzi, Tom Stiff, Penny A. Jeggo
      Pages 53-77

    5. Chromatin Responses to DNA Damage

      • Karina Falbo, Xuetong Shen
      Pages 79-100

    6. Caenorhabditis elegans Radiation Responses

      • Aymeric Bailly, Anton Gartner
      Pages 101-123

  3. Modulation of Radiation Responses: Opportunities for Therapeutic Exploitation

    1. Front Matter

      Pages 125-125
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  4. Modulation of Radiation Responses – Opportunities for Therapeutic Exploitation

    1. Hypoxia and Modulation of Cellular Radiation Response

      • Ester M. Hammond, Monica Olcina, Amato J. Giaccia
      Pages 127-141

    2. Inhibitors of DNA Repair and Response to Ionising Radiation

      • Barbara Vischioni, Nils H. Nicolay, Ricky A. Sharma, Thomas Helleday
      Pages 143-171

    3. Gene Therapy and Radiation

      • Svend O. Freytag, Kenneth N. Barton, Farzan Siddiqui, Mohamed Elshaikh, Hans Stricker, Benjamin Movsas
      Pages 173-186

    4. Molecular Targeted Drug Delivery Radiotherapy

      • Eugenia M. Yazlovitskaya, Dennis E. Hallahan
      Pages 187-200

    5. EGFR Signaling and Radiation

      • Emily F. Dunn, Shyhmin Huang, Paul M. Harari
      Pages 201-226

    6. Thermal Modulation of Radiation-Induced DNA Damage Responses

      • Joseph L. Roti Roti, Robert P. VanderWaal, Andrei Laszlo
      Pages 227-249

    7. Radiation-Induced Immune Modulation

      • Charles G. Drake
      Pages 251-263

  5. Back Matter

    Pages 265-276
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Keywords

About this book

Molecular Determinants of Radiation Response includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins. The chapters include comprehensive discussions on where and how specific alterations in function of these pathways and proteins result in substantive modifications of cellular response to DNA injury. Given the importance of therapies that induce DNA injury in the management of human disease, this book is timely and relevant for basic and translational researchers, as well as clinicians alike.

Editors and Affiliations

  • Dept. Radiation Oncology, Johns Hopkins University, Baltimore, USA

    Theodore L. DeWeese, Marikki Laiho

Bibliographic Information

  • Book Title: Molecular Determinants of Radiation Response

  • Editors: Theodore L. DeWeese, Marikki Laiho

  • Series Title: Current Cancer Research

  • DOI: https://doi.org/10.1007/978-1-4419-8044-1

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2011

  • Hardcover ISBN: 978-1-4419-8043-4Published: 16 March 2011

  • Softcover ISBN: 978-1-4614-2832-9Published: 19 April 2013

  • eBook ISBN: 978-1-4419-8044-1Published: 23 March 2011

  • Series ISSN: 2199-2584

  • Series E-ISSN: 2199-2592

  • Edition Number: 1

  • Number of Pages: XVI, 276

  • Topics: Cancer Research, Pharmacology/Toxicology

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