The Circadian Clock

1. Front Matter

   Pages i-xi

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2. A History of Chronobiological Concepts

   • Serge Daan

   Pages 1-35

3. Transcriptional Regulation of Circadian Clocks

   • Jürgen A. Ripperger, Steven A. Brown

   Pages 37-78

4. Posttranslational Regulation of Circadian Clocks

   • Jens T. Vanselow, Achim Kramer

   Pages 79-104

5. Nonimage Forming Photoreceptors

   • Stuart N. Peirson, Russell G. Foster

   Pages 105-113

6. Circadian Clocks and Metabolism

   • Henrik Oster

   Pages 115-137

7. Circadian Clock, Cell Cycle and Cancer

   • Zhaoyang Zhao, Cheng Chi Lee

   Pages 139-155

8. Comparative Clocks

   • Martha Merrow, David Lenssen, Till Roenneberg

   Pages 157-177

9. Circadian Neural Networks

   • Erik D. Herzog, Paul H. Taghert

   Pages 179-194

10. The Circadian Clock and the Homeostatic Hourglass: Two Timepieces Controlling Sleep and Wakefulness

    • Sarah Laxhmi Chellappa, Christian Cajochen

    Pages 195-228

11. Clocks, Brain Function, and Dysfunction

    • Céline Feillet, Urs Albrecht

    Pages 229-282

12. Systems Biology and Modeling of Circadian Rhythms

    • Thomas d’Eysmond, Felix Naef

    Pages 283-293

13. Back Matter

    Pages 295-300

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With the invitation to edit this volume, I wanted to take the opportunity to assemble reviews on different aspects of circadian clocks and rhythms. Although most c- tributions in this volume focus on mammalian circadian clocks, the historical int- duction and comparative clocks section illustrate the importance of various other organisms in deciphering the mechanisms and principles of circadian biology. Circadian rhythms have been studied for centuries, but only recently, a mole- lar understanding of this process has emerged. This has taken research on circadian clocks from mystic phenomenology to a mechanistic level; chains of molecular events can describe phenomena with remarkable accuracy. Nevertheless, current models of the functioning of circadian clocks are still rudimentary. This is not due to the faultiness of discovered mechanisms, but due to the lack of undiscovered processes involved in contributing to circadian rhythmicity. We know for example, that the general circadian mechanism is not regulated equally in all tissues of m- mals. Hence, a lot still needs to be discovered to get a full understanding of cir- dian rhythms at the systems level. In this respect, technology has advanced at high speed in the last years and provided us with data illustrating the sheer complexity of regulation of physiological processes in organisms. To handle this information, computer aided integration of the results is of utmost importance in order to d- cover novel concepts that ultimately need to be tested experimentally.

• Neural Network
• Regulation
• Translation
• albrecht
• biochemistry
• circadian
• clock
• physiology
• protein
• reviews
• transcription

• Inst. Biochimie, Université de Fribourg, Fribourg, Switzerland

  Urs Albrecht

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