Energy Balance and Gastrointestinal Cancer

1. Front Matter

   Pages i-xii

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2. Obesity and Gastrointestinal Cancers: Epidemiology

   • Nora L. Nock

   Pages 1-22

3. Genetics of Colon Cancer Susceptibility

   • Graham Casey

   Pages 23-45

4. Dietary Modulation of Colon Cancer: Effects on Intermediary Metabolism, Mucosal Cell Differentiation, and Inflammation

   • Lidija Klampfer, Barbara G. Heerdt, Anna Velcich, Erin Gaffney-Stomberg, Donghai Wang, Elaine Lin et al.

   Pages 47-64

5. The ApcMin/+ Mouse Model to Study the Effects of Exercise on Gastrointestinal Malignancy

   • Nathan A. Berger

   Pages 65-75

6. Obesity and the Pathogenesis of Barrett’s Esophagus

   • Rom Leidner, Amitabh Chak

   Pages 77-92

7. Obesity and Pancreatic Cancer

   • Donghui Li

   Pages 93-109

8. Obesity, Insulin Resistance Pathway Factors, and Colon Cancer

   • Li Li

   Pages 111-129

9. Ras/Raf and Their Influence in Glycolysis in Colon Cancer

   • Fred Bunz, Nickolas Papadopoulos

   Pages 131-139

10. Energy Balance and Other Modifiable Host Factors on Colorectal Cancer Prognosis

    • Jeffrey Meyerhardt

    Pages 141-156

11. Cyclooxygenase-2 and Chronic Inflammation: Drivers of Colorectal Tumorigenesis

    • Monica M. Bertagnolli

    Pages 157-182

12. Back Matter

    Pages 183-184

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The gastrointestinal track provides one of the distinct systems where multiple malignancies, including adenocarcinoma of the pancreas, esophagus and colon are each associated with obesity. This unique association is covered in this volume of Energy Balance and Cancer from the epidemiologic, biologic and potential etiologic viewpoint. The focus on possible dietary contribution as well as the role of exercise in prevention and therapy is presented in both animal model and patient based studies. Special focus is provided also on the role of genetic mutations and inflammatory pathways as drivers of these obesity related gastrointestinal malignancies. Overall, this volume on Energy Balance and Gastrointestinal Malignancies should be valuable to Epidemiologists, Gastroenterologists and Oncologists, as well as to students and researchers from multiple disciplines interested in understanding and disrupting the association between obesity and cancer.

• Barrett's Esophagus
• colon cancer
• colorectal cancer
• cyclooxygenase-2
• gastrointestinal cancer

From the reviews:

“In this book, leading investigators present a crossdisciplinary (basic, translational, and clinical science) view of the current state of the science on the links between gastrointestinal malignancy and energy balance. … aimed at epidemiologists, gastroenterologists, and oncologists as well as students and researchers interested in understanding the connection between obesity and GI cancers … .” (Willem J. de Villiers, Doody’s Review Service, July, 2012)

• , Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, USA

  Sanford D. Markowitz

• School of Medicine, Center for Science, Health & Society, Case Western Reserve University, Cleveland, USA

  Nathan A. Berger

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