Myelin Repair and Neuroprotection in Multiple Sclerosis

Editors: Duncan, Ian D., Franklin, Robin J M (Eds.)

  • First book on this topic
  • Authorship from many of the major players in the field of MS and myelin repair
  • Of equal interest to academic clinical neurologists and neuroscientists
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Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-1-4614-2218-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4614-2217-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-1-4899-8840-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Myelin Repair and Neuroprotection in Multiple Sclerosis presents an up-date on the translational potential of promoting remyelination in multiple sclerosis (MS).  A number of research frontiers still exist in this challenging disease.  The cause remains elusive, preventing breakthroughs in its prevention.  The move towards oral immunomodulatory therapies has been a major advance, as has the finding of new genes linked to susceptibility that may open the door to new therapeutic approaches.  However, a frontier that has been making significant strides in recent years has been that surrounding the neurobiology of myelin regeneration and axon protection: such have been the advances that clinical translation is on the cusp of being achieved. Two broad approaches to therapeutic enhancement of remyelination are envisaged: promoting endogenous remyelination by targeting cells present in the CNS, or, replacing lost myelinating cells from exogenous sources.  Current research on oligodendrocyte biology, the pathology of MS, imaging of lesions and the biology of remyelination are paving the way toward opening this new translational frontier.

 

Professor Duncan and Professor Franklin have assembled a broad group of experts in the fields of glial cell biology, neuropathology, radiology and clinical neurology to provide the background toward taking remyelination from experimented models into MS patients. 

Reviews

From the book reviews:

“The textbook discusses the cellular and molecular mediators of demyelination and regeneration of myelin support. It does a credible and well evidenced job at these two goals. National and international experts contribute to the dialogue. … I recommend this book to neurologists, neuroscientists, neurosurgeons … .” (Joseph J. Grenier, Amazon.com, August, 2014)


Table of contents (11 chapters)

  • Development of Oligodendrocytes in the Vertebrate CNS

    Miller, Robert H.

    Pages 1-21

  • Demyelination and Remyelination in Multiple Sclerosis

    Bø, Lars (et al.)

    Pages 23-45

  • Microglial Function in MS Pathology

    Kilpatrick, Trevor J. (et al.)

    Pages 47-70

  • Endogenous Remyelination in the CNS

    Franklin, Robin J. M. (et al.)

    Pages 71-92

  • Exogenous Cell Myelin Repair and Neuroprotection in Multiple Sclerosis

    Duncan, Ian D. (et al.)

    Pages 93-127

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-1-4614-2218-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4614-2217-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-1-4899-8840-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Myelin Repair and Neuroprotection in Multiple Sclerosis
Editors
  • Ian D. Duncan
  • Robin J M Franklin
Copyright
2013
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-2218-1
DOI
10.1007/978-1-4614-2218-1
Hardcover ISBN
978-1-4614-2217-4
Softcover ISBN
978-1-4899-8840-9
Edition Number
1
Number of Pages
XIV, 290
Topics