Overview
- Reviews signaling pathways in the regulation of circulatory and respiratory function
- Describes ion and molecular carriers and receptors
- Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows
- Includes supplementary material: sn.pub/extras
Part of the book series: Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems (BBMCVS, volume 3)
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Table of contents (12 chapters)
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Front Matter
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Back Matter
Keywords
- blood flow behavior
- blood flow prediction
- cardiovascular systems modeling
- cell signalling pathways
- ion and molecule carriers described
- modeling respiratory function
- modeling simulation of flows
- physiological flows
- receptors ligands
- signaling mediators explained
- ventilatory systems modeling
- Systems Biology
About this book
The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning.
Volume 3 is devoted to the set of mediators of the cell surface, especially ion and molecular carriers and catalytic receptors that, once liganded and activated, initiate signal transduction pathways. Intracellular cascades of chemical reactions trigger the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Primary mediators are included in models of regulated cellular processes, but multiple secondary signaling components are discarded to allow simple, representative modeling and to manage their inverse problems.
Authors and Affiliations
Bibliographic Information
Book Title: Signaling at the Cell Surface in the Circulatory and Ventilatory Systems
Authors: Marc Thiriet
Series Title: Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems
DOI: https://doi.org/10.1007/978-1-4614-1991-4
Publisher: Springer New York, NY
eBook Packages: Physics and Astronomy, Physics and Astronomy (R0)
Copyright Information: Springer Science+Business Media, LLC 2012
Hardcover ISBN: 978-1-4614-1990-7Published: 13 December 2011
Softcover ISBN: 978-1-4939-5204-5Published: 23 August 2016
eBook ISBN: 978-1-4614-1991-4Published: 14 December 2011
Series ISSN: 2193-1682
Series E-ISSN: 2193-1690
Edition Number: 1
Number of Pages: XV, 982
Topics: Biological and Medical Physics, Biophysics, Biomedical Engineering and Bioengineering, Mathematical and Computational Biology, Systems Biology, Engineering Fluid Dynamics, Cardiology