Editors:
- Contains up-to-date research
- Written by field experts
- In-depth look at a complex topic
- Includes supplementary material: sn.pub/extras
Part of the book series: Current Topics in Neurotoxicity (Current Topics Neurotoxicity, volume 1)
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Table of contents (11 chapters)
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Front Matter
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Isoquinolines as Neurotoxins and Neuroprotectants
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Front Matter
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Isoquinolines as neurotoxins and neuroprotectants
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β-Carbolines as Neurotoxins and Neuroprotectants
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Front Matter
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Beta-carbolines as neurotoxins and neuroprotectants
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Back Matter
About this book
The specific topic, “Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants – New Perspectives In Parkinson`S Disease Therapy,” was chosen in light of accumulating neurobiological evidence indicating that, in addition to exogenous neurotoxins (e.g., 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP]), endogenous compounds may play an important role in the most common neurodegenerative disorders (e.g., Parkinson`s disease). Two groups of amine related compounds, which appeared chemically like MPTP, were detected in human brain and cerebrospinal fluid (CSF): ß-carbolines (BCs) and tetrahydroisoquinolines (TIQs). These are heterocyclic compounds formed endogenously from phenylalanine/tyrosine (TIQs) and tryptophan, tryptamine, and 5-hydroxytryptamine (BCs), respectively and exert a wide spectrum of psychopharmacological and behavioral effects. The TIQs and BCs may bind to their own high affinity sites on neuronal membranes associated with or located close to the receptors of neurotransmitters. Research on TIQs and BCs is stimulated also by their possible role in pathological conditions, especially parkinsonism and alcoholism. Recently, clinical interest has been spurred by their role as neuroprotective, and even neurorestorative, anticonvulsant and antiaddictive, substances.
In this book we are going to summarize, for the first time, the results from behavioral, neurochemical and molecular experiments, which demonstrate a wide spectrum of TIQs and BCs effects - from their rather mild neurotoxic actions to the important neuroprotective and antiaddictive properties.
Additionally, the recent results of experimental studies in vivo have allowed a much better understanding and simultaneous comparison of the neurochemical and molecular mechanisms underlying the neuroprotective and neurotoxic actions of endogenous TIQs and BCs and have pointed to the possibility oftheir therapeutic applications in neurodegenerative diseases such as Parkinson's disease.
Editors and Affiliations
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Krakow, Poland
Lucyna Antkiewicz-Michaluk
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, Departments of Psychiatry, Charité-University Medicine, Berlin, Germany
Hans Rommelspacher
Bibliographic Information
Book Title: Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants
Book Subtitle: New Vistas In Parkinson's Disease Therapy
Editors: Lucyna Antkiewicz-Michaluk, Hans Rommelspacher
Series Title: Current Topics in Neurotoxicity
DOI: https://doi.org/10.1007/978-1-4614-1542-8
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2012
Hardcover ISBN: 978-1-4614-1541-1Published: 06 December 2011
Softcover ISBN: 978-1-4899-8754-9Published: 03 March 2014
eBook ISBN: 978-1-4614-1542-8Published: 07 December 2011
Series ISSN: 2363-9563
Series E-ISSN: 2363-9571
Edition Number: 1
Number of Pages: X, 178
Topics: Neurosciences, Neurochemistry, Pharmacy