Current Topics in Neurotoxicity

Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants

New Vistas In Parkinson's Disease Therapy

Editors: Antkiewicz-Michaluk, Lucyna, Rommelspacher, Hans (Eds.)

  • Contains up-to-date research
  • Written by field experts
  • In-depth look at a complex topic
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About this book

       The specific topic, “Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants – New Perspectives In Parkinson`S Disease Therapy,” was chosen in light of accumulating neurobiological evidence indicating that, in addition to exogenous neurotoxins (e.g., 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP]), endogenous compounds may play an important role in the most common neurodegenerative disorders (e.g., Parkinson`s disease). Two groups of amine related compounds, which appeared chemically like MPTP, were detected in human brain and cerebrospinal fluid (CSF): ß-carbolines (BCs) and tetrahydroisoquinolines  (TIQs). These are heterocyclic compounds formed endogenously from phenylalanine/tyrosine (TIQs) and tryptophan, tryptamine, and 5-hydroxytryptamine (BCs), respectively and exert a wide spectrum of psychopharmacological and behavioral effects. The TIQs and BCs may bind to their own high affinity sites on neuronal membranes associated with or located close to the receptors of neurotransmitters. Research on TIQs and BCs is stimulated also by their possible role in pathological conditions, especially parkinsonism and alcoholism. Recently, clinical interest has been spurred by their role as neuroprotective, and even neurorestorative, anticonvulsant and antiaddictive, substances.

           

In this book we are going to summarize, for the first time, the results from behavioral, neurochemical and molecular experiments, which demonstrate a wide spectrum of TIQs and BCs effects - from their rather mild neurotoxic actions to the important neuroprotective and antiaddictive properties.

Additionally, the recent results of experimental studies in vivo have allowed a much better understanding and simultaneous comparison of the neurochemical and molecular mechanisms underlying the neuroprotective and neurotoxic actions of endogenous TIQs and BCs and have pointed to the possibility of their therapeutic applications in neurodegenerative diseases such as Parkinson's disease.

Table of contents (11 chapters)

  • Two Faces of 1,2,3,4-Tetrahydroisoquinoline Mode of Action in the Mammalian Brain: Is It an Endogenous Neurotoxin or a Neuromodulator?

    Lorenc-Koci, Elżbieta

    Pages 3-30

  • Isoquinolines as Neurotoxins: Action and Molecular Mechanism

    Wąsik, Agnieszka (et al.)

    Pages 31-43

  • 1-Methyl-1,2,3,4-Tetrahydroisoquinoline: A Potent Neuroprotecting Agent

    Vetulani, Jerzy (et al.)

    Pages 45-56

  • 1-Methyl-1,2,3,4-Tetrahydroisoquinoline and Addiction: Experimental Studies

    Antkiewicz-Michaluk, Lucyna (et al.)

    Pages 57-74

  • β-Carbolines as Neurotoxins

    Herraiz, Tomás

    Pages 77-103

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-1-4614-1542-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-1-4614-1541-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4899-8754-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants
Book Subtitle
New Vistas In Parkinson's Disease Therapy
Editors
  • Lucyna Antkiewicz-Michaluk
  • Hans Rommelspacher
Series Title
Current Topics in Neurotoxicity
Series Volume
1
Copyright
2012
Publisher
Springer US
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4614-1542-8
DOI
10.1007/978-1-4614-1542-8
Hardcover ISBN
978-1-4614-1541-1
Softcover ISBN
978-1-4899-8754-9
Series ISSN
2363-9563
Edition Number
1
Number of Pages
X, 178
Topics