Antibiotic Discovery and Development

Editors: Dougherty, Thomas J., Pucci, Michael J. (Eds.)

  • Chapters written by experts in their fields
  • Contains helpful, full-color illustrations
  • Features up-to-date research
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eBook $459.00
price for USA (gross)
  • ISBN 978-1-4614-1400-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $579.00
price for USA
  • ISBN 978-1-4614-1399-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.

Table of contents (37 chapters)

  • The Early History of Antibiotic Discovery: Empiricism Ruled

    White, Richard J.

    Pages 3-31

  • Rational Approaches to Antibacterial Discovery: Pre-Genomic Directed and Phenotypic Screening

    Silver, Lynn L.

    Pages 33-75

  • Beta-Lactam Antibiotics

    Page, Malcolm G. P.

    Pages 79-117

  • Review of the Quinolone Family

    Jacoby, George A. (et al.)

    Pages 119-146

  • Tetracyclines

    Bradford, Patricia A. (et al.)

    Pages 147-179

Buy this book

eBook $459.00
price for USA (gross)
  • ISBN 978-1-4614-1400-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $579.00
price for USA
  • ISBN 978-1-4614-1399-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Antibiotic Discovery and Development
Editors
  • Thomas J. Dougherty
  • Michael J. Pucci
Copyright
2012
Publisher
Springer US
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4614-1400-1
DOI
10.1007/978-1-4614-1400-1
Hardcover ISBN
978-1-4614-1399-8
Edition Number
1
Number of Pages
XVII, 1127
Topics