Advances in Experimental Medicine and Biology

Endocrine FGFs and Klothos

Editors: Kuro-o, Makoto (Ed.)

  • Discusses potential of FGF23 and Klotho as novel diagnostic markers and therapeutic targets for chronic kidney disease
  • Gives an overview of current knowledge on FGF19 and FGF21
  • Comprehensive in scope
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eBook $179.00
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  • ISBN 978-1-4614-0887-1
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Hardcover $229.00
price for USA
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  • ISBN 978-1-4614-0886-4
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About this book

Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors.

About the authors

MAKOTO KURO-O is an Associate Professor in the Pathology Department at the University of Texas Southwestern Medical Center at Dallas (UT Southwestern). He also has an appointment to the Pak Center for Mineral Metabolism and the Simmons Comprehensive Cancer Center in UT Southwestern. He received his MD and PhD from the University of Tokyo, Japan. His major research interests include molecular mechanisms of aging and age-related diseases with special reference to chronic kidney disease. He is a member of the American Society of Nephrology (ASN).

Table of contents (14 chapters)

  • The Structural Biology of the FGF19 Subfamily

    Beenken, Andrew (et al.)

    Pages 1-24

  • Klotho and βKlotho

    Kuro-o, Makoto

    Pages 25-40

  • FGF23 and Syndromes of Abnormal Renal Phosphate Handling

    Bergwitz, Clemens (et al.)

    Pages 41-64

  • Evidence for FGF23 Involvement in a Bone-Kidney Axis Regulating Bone Mineralization and Systemic Phosphate and Vitamin D Homeostasis

    Martin, Aline (et al.)

    Pages 65-83

  • FGF23, Klotho and Vitamin D Interactions:

    Razzaque, M. Shawkat

    Pages 84-91

Buy this book

eBook $179.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-1-4614-0887-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $229.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4614-0886-4
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
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Bibliographic Information

Bibliographic Information
Book Title
Endocrine FGFs and Klothos
Editors
  • Makoto Kuro-o
Series Title
Advances in Experimental Medicine and Biology
Series Volume
728
Copyright
2012
Publisher
Springer-Verlag New York
Copyright Holder
Landes Bioscience and Springer Science+Business Media, LLC
eBook ISBN
978-1-4614-0887-1
DOI
10.1007/978-1-4614-0887-1
Hardcover ISBN
978-1-4614-0886-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XX, 210
Number of Illustrations and Tables
37 b/w illustrations, 1 illustrations in colour
Topics