Advances in Experimental Medicine and Biology

Fuzziness

Structural Disorder in Protein Complexes

Editors: Fuxreiter, Monika, Tompa, Peter (Eds.)

  • Gives characterization of fuzzy interactions
  • Provides a broad overview of the phenomenon of fuzziness in molecular interactions
  • Summarizes the current state of knowledge in this new field
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Hardcover $259.00
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About this book

Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.

About the authors

MONIKA FUXREITER is a senior scientist at the Institute of Enzymology, Hungarian Academy of Sciences in Budapest, Hungary and a visiting scientist at the Weizmann Institute of Science, in Rehovot, Israel. Her main interest is to develop mechanistic models for proteins, especially structure-function relationships for intrinsically disordered proteins and their complexes. She also studies the role of dynamism in protein evolution. She often shares ideas with her children, Krisztina and Pal. Monika Fuxreiter received her degrees from the Eötvös Loránd University, Budapest, Hungary.

PETER TO MPA is a professor of protein sciences at the Institute of Enzymology of the Hungarian Academy of Sciences, Budapest, Hungary. His interest focuses on the structural disorder of proteins, a phenomenon that defies the classical structure-function paradigm of proteins that is about to change our general concepts of protein structure and function. He made basic contributions to this field, he organized the first international meeting dedicated to this topic in 2007 and wrote the first monograph on structural disorder (Structure and function of intrinsically disordered proteins, 2009, CRC Press, a Taylor and Francis group, Boca Raton Fl). He has published over 100 papers in international journals and holds a DSc degree from the Hungarian Academy of Sciences. Recently he took the position of director at the VIB Department of Structural Biology, Brussels, Belgium.

Table of contents (11 chapters)

  • Fuzzy Complexes: A More Stochastic View of Protein Function

    Fuxreiter, Monika (et al.)

    Pages 1-14

  • Dynamic Fuzziness During Linker Histone Action

    McBryant, Steven J. (et al.)

    Pages 15-26

  • Intrinsic Protein Flexibility in Regulation of Cell Proliferation: Advantages for Signaling and Opportunities for Novel Therapeutics

    Follis, Ariele Viacava (et al.)

    Pages 27-49

  • Interplay Between Protein Order, Disorder and Oligomericity in Receptor Signaling

    Sigalov, Alexander B.

    Pages 50-73

  • Consequences of Fuzziness in the NFκB/IκBα Interaction

    Komives, Elizabeth A.

    Pages 74-85

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-1-4614-0659-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-1-4614-0658-7
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
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Bibliographic Information

Bibliographic Information
Book Title
Fuzziness
Book Subtitle
Structural Disorder in Protein Complexes
Editors
  • Monika Fuxreiter
  • Peter Tompa
Series Title
Advances in Experimental Medicine and Biology
Series Volume
725
Copyright
2012
Publisher
Springer-Verlag New York
Copyright Holder
Landes Bioscience and Springer Science+Business Media, LLC
eBook ISBN
978-1-4614-0659-4
DOI
10.1007/978-1-4614-0659-4
Hardcover ISBN
978-1-4614-0658-7
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XX, 190
Number of Illustrations and Tables
46 b/w illustrations, 4 illustrations in colour
Topics