Cancer Drug Discovery and Development

DNA Topoisomerases and Cancer

Editors: Pommier, Yves (Ed.)

  • Structure and mechanism of eukaryotic type IIA topoisomerases
  • DNA topoisomerase I and illegitimate recombination
  • Mechanism regulating cellular responses to DNA topoisomerase I-targeted agents
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eBook $229.00
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  • ISBN 978-1-4614-0323-4
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Hardcover $289.00
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  • ISBN 978-1-4614-0322-7
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About this book

DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for the cancer-relevant topoisomerases. It will describe how topoisomerase dysfunctions can damage the genome and increase the risk of cancers, and the involvement of topoisomerases in programmed cell death. The book will also present the various topoisomerase inhibitors in clinical use and development and their molecular and cellular mechanisms of action.

Table of contents (19 chapters)

  • Introduction and Historical Perspective

    Forterre, Patrick

    Pages 1-52

  • Human DNA Topoisomerase I: Structure, Enzymology and Biology

    Champoux, James J.

    Pages 53-69

  • Mitochondrial Topoisomerases

    Rosa, Ilaria Dalla (et al.)

    Pages 71-85

  • Structure and Mechanism of Eukaryotic Type IIA Topoisomerases

    Berger, James M. (et al.)

    Pages 87-101

  • Essential Functions of Topoisomerase IIIα in the Nucleus and Mitochondria

    Chen, Stefanie Hartman (et al.)

    Pages 103-117

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-4614-0323-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-4614-0322-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-4614-2963-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
DNA Topoisomerases and Cancer
Editors
  • Yves Pommier
Series Title
Cancer Drug Discovery and Development
Copyright
2012
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4614-0323-4
DOI
10.1007/978-1-4614-0323-4
Hardcover ISBN
978-1-4614-0322-7
Softcover ISBN
978-1-4614-2963-0
Series ISSN
2196-9906
Edition Number
1
Number of Pages
XI, 443
Number of Illustrations and Tables
16 b/w illustrations, 49 illustrations in colour
Topics