Overview
- Editors:
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Barry B. Bercu
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Pediatric Endocrinology, All Children’s Hospital, St. Petersburg, USA
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Richard F. Walker
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Pediatric Endocrinology, All Children’s Hospital, St. Petersburg, USA
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Table of contents (27 papers)
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Somatostatin/GRF Regulation
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- David H. Coy, William A. Murphy, Simon J. Hocart, John Taylor
Pages 3-16
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- Jacob Kraicer, Stephen M. Sims
Pages 17-32
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- Terry Reisine, Karen Raynor, Haeyoung Kong, Susan F. Law, Magali Theveniau, Melanie Tallent et al.
Pages 33-46
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- Diane Prager, Shlomo Melmed
Pages 73-84
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The Immune System and Growth Hormone Interaction
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- Keith W. Kelley, Sean Arkins, Yong Ming Li
Pages 87-103
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- Douglas A. Weigent, J. Edwin Blalock
Pages 104-115
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- Nicola Fabris, Eugenio Mocchegiani
Pages 116-130
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Novel Aspects of Growth Hormone Research I
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Front Matter
Pages 131-131
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- Lester Cohn, Axel G. Feller, Inge W. Rudman, Daniel Rudman
Pages 133-149
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- Robert Marcus, Leah Holloway, Gail E. Butterfield
Pages 150-154
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- Thierry Abribat, Nathalie Deslauriers, Isabelle Reeves, Dominique R. Garrel, Paul Brazeau
Pages 155-166
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- Richard F. Walker, Sei-Won Yang, Ryuji Masuda, Cheng-Shih Hu, Barry B. Bercu
Pages 167-192
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Novel Aspects of Growth Hormone Research II
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Front Matter
Pages 201-201
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- C. Y. Bowers, K. Veeraragavan, K. Sethumadhavan
Pages 203-222
About this book
This book is a compendium of proceedings from the Symposium on Growth Hormone II: Basic and Clinical Aspects. The intent of the sym posium was to review current aspects of the rapidly expanding science of growth hormone (GH) neuroendocrinology, especially those develop ments that occurred since our last meeting in 1985. The meeting was timely since there have been many new and exciting developments in basic research on the GH axis, and several new clinical applications for GH other than growth have been identified. For example, significant strides have been made into use of the bioengineered hormone as an anabolic in debilitated states and as an immunorestorative agent. Both these areas have received most attention as they relate to geriatric popu lations. Furthermore, recent focus on a novel family of GH secretagogues that complement the action of GHRH has shown that in animal models, these compounds have the potential to restore GH secretion in deficient or insufficient states, including growth retardation, obesity, and aging. Accordingly, these xenobiotics may have significant potential as drug products to stimulate physiological GH secretion and, thus, resist or reverse some of the maladaptive changes in form and function resulting from GH insufficiency. The importance of these agents as drug candidates is underscored by the diversity of molecules that have been studied by various pharmaceutical companies and the recent discovery that non peptide analogs with high oral bioavailability can be synthesized.
