Serono Symposia USA

Growth Hormone II

Basic and Clinical Aspects

Editors: Bercu, Barry B., Walker, Richard F. (Eds.)

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About this book

This book is a compendium of proceedings from the Symposium on Growth Hormone II: Basic and Clinical Aspects. The intent of the sym­ posium was to review current aspects of the rapidly expanding science of growth hormone (GH) neuroendocrinology, especially those develop­ ments that occurred since our last meeting in 1985. The meeting was timely since there have been many new and exciting developments in basic research on the GH axis, and several new clinical applications for GH other than growth have been identified. For example, significant strides have been made into use of the bioengineered hormone as an anabolic in debilitated states and as an immunorestorative agent. Both these areas have received most attention as they relate to geriatric popu­ lations. Furthermore, recent focus on a novel family of GH secretagogues that complement the action of GHRH has shown that in animal models, these compounds have the potential to restore GH secretion in deficient or insufficient states, including growth retardation, obesity, and aging. Accordingly, these xenobiotics may have significant potential as drug products to stimulate physiological GH secretion and, thus, resist or reverse some of the maladaptive changes in form and function resulting from GH insufficiency. The importance of these agents as drug candidates is underscored by the diversity of molecules that have been studied by various pharmaceutical companies and the recent discovery that non­ peptide analogs with high oral bioavailability can be synthesized.

Table of contents (27 chapters)

  • Pharmacology of GRF and Somatostatin: Positive and Negative Control of GH Release

    Coy, David H. (et al.)

    Pages 3-16

  • Ionic Mechanisms Governing the Control of Growth Hormone Secretion by Somatostatin

    Kraicer, Jacob (et al.)

    Pages 17-32

  • Biochemical and Functional Properties of Somatostatin Receptors

    Reisine, Terry (et al.)

    Pages 33-46

  • Regulation of Growth Hormone Output: The GRF Signal

    Robinson, I. C. A. F.

    Pages 47-65

  • Regulation of Growth Hormone Secretion in Man

    Vance, Mary Lee

    Pages 66-72

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-1-4613-8372-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.00
price for USA
  • ISBN 978-1-4613-8374-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Growth Hormone II
Book Subtitle
Basic and Clinical Aspects
Editors
  • Barry B. Bercu
  • Richard F. Walker
Series Title
Serono Symposia USA
Copyright
1994
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York, Inc.
eBook ISBN
978-1-4613-8372-7
DOI
10.1007/978-1-4613-8372-7
Softcover ISBN
978-1-4613-8374-1
Edition Number
1
Number of Pages
XX, 379
Topics