Advances in Experimental Medicine and Biology

Mechanisms of Lymphocyte Activation and Immune Regulation IV

Cellular Communications

Editors: Gupta, Sudhir, Waldmann, Thomas (Eds.)

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About this book

In recent years rapid progress has been made in the areas of T cell and B cell biology, cell-cell and cell-matrix/stroma interactions. The use of isolated subunits of the T cell receptor invariant chains has been instrumental in defining their role in signal transduction and tyrosine phosphorylation. A role of src family phosphotyrosine kinases in T cell activation has been demonstrated and several phosphotyrosine kinase substrates have been identified and their functions characterized. Homologous recombinant techniques have led to the development of murine strains that lack CD4 or CD8 expression. These models are likely to be instrumental in studying the role of T cell subsets in autoimmune disorders, tissue transplant rejection and tumor rejection. A role of major histocompatibility complex I in the development of T cell subsets and NK cells has been defined. Recent data suggest a role of interaction between plasma membrane molecules of activated T helper cells and B cells, B cells primed with plasma membrane of activated T helper cells and cytokines, and interaction between bone marrow stromal cells and B cell progenitors and precursors, in the B cell development, proliferation, and differentiation. The structure and functions of adhesion molecules, especially with regard to signal transduction and homing events, are better defined.

Table of contents (23 chapters)

  • T Cell Receptor Structure and Function: Analysis by Expression of Portions of Isolated Subunits

    Engel, Isaac (et al.)

    Pages 1-7

  • The T Cell Antigen Receptor Tyrosine Kinase Pathway

    Samelson, Lawrence E. (et al.)

    Pages 9-16

  • Dissection of the Hb(64–76) Determinant Reveals That the T Cell Receptor May Have the Capacity to Differentially Signal

    Evavold, Brian D. (et al.)

    Pages 17-21

  • CD28 Receptor Crosslinking Induces Tyrosine Phosphorylation of PLCγ1

    Ledbetter, Jeffrey A. (et al.)

    Pages 23-27

  • Structure and Function of CD45: A Leukocyte-Specific Protein Tyrosine Phosphatase

    Trowbridge, Ian S. (et al.)

    Pages 29-37

Buy this book

eBook $89.00
price for USA (gross)
  • ISBN 978-1-4615-3396-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $119.00
price for USA
  • ISBN 978-1-4613-6500-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mechanisms of Lymphocyte Activation and Immune Regulation IV
Book Subtitle
Cellular Communications
Editors
  • Sudhir Gupta
  • Thomas Waldmann
Series Title
Advances in Experimental Medicine and Biology
Series Volume
323
Copyright
1992
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-3396-2
DOI
10.1007/978-1-4615-3396-2
Softcover ISBN
978-1-4613-6500-6
Series ISSN
0065-2598
Edition Number
1
Number of Pages
IX, 204
Topics