Nato Science Series A:

Oncogene and Transgenics Correlates of Cancer Risk Assessments

Editors: Zervos, Constantine (Ed.)

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About this book

The data, the information, and even the overarching knowledge necessary for risk assessments of economically important environmental carcinogens come, for the most part, from the applied biological disciplines, e. g. , toxicology, epidemiology, biostatistics, etc. The more fundamental biological disciplines, e. g. , biochemistry, cell biology, molecular biology, molecular genetics of cancer, etc. , have enormous but unrealized potential to improve current cancer risk assessment methods. The objective of this advanced research workshop ARW was to advance the state of the art of cancer risk assessment methods by identifying potential short and long term contributions to such methods from the more fundamental disciplines. Attention was paid to short and long term contributions from research advances in the biochemistry and physiology of oncogenes (oncogenes research) and in the construction and utilization of transgenic animals (transgenics research). In the last 20 years, researchers in the fundamental biological disciplines, i. e. , biochemists, geneticists, molecular and cell biologists, etc. , have, inter alia, advanced spectacularly our understanding of the nature of neoplastic diseases. Their phenomenal progress is the combined result of both advances and refinements of the techniques available to them and of new fundamental discoveries. Among the latter the most significant are the discoveries of oncogenes and of the feasibility of creating transgenic animals, i. e. , of transferring well defined and expressible genes from the cells of one species of organisms to the embryonic cells of another.

Table of contents (23 chapters)

  • Cancer Risk Assessments: An Overview

    Anderson, Elizabeth L.

    Pages 1-20

  • Pharmacodynamic Models for Cancer Risk Assessment

    Moolgavkar, Suresh H.

    Pages 21-29

  • Predictive Value for Cancer Risk Assessment of Cell- and Tissue- Specific Formation of Carcinogen-DNA Adducts

    Scherer, Ewalt

    Pages 31-42

  • Studies on the Role of Protein Kinase C in Multistage Carcinogenesis and Their Relevance to Risk Extrapolation

    O’Driscoll, Kevin R. (et al.)

    Pages 43-59

  • Oncogene Activation and Human Cancer

    Spandidos, Demetrios A. (et al.)

    Pages 61-66

Buy this book

eBook $74.99
price for USA (gross)
  • ISBN 978-1-4615-3056-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $99.00
price for USA
  • ISBN 978-1-4613-6333-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Oncogene and Transgenics Correlates of Cancer Risk Assessments
Editors
  • Constantine Zervos
Series Title
Nato Science Series A:
Series Volume
232
Copyright
1992
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-3056-5
DOI
10.1007/978-1-4615-3056-5
Softcover ISBN
978-1-4613-6333-0
Edition Number
1
Number of Pages
XI, 351
Topics