Advances in Experimental Medicine and Biology

Mechanisms of Platelet Activation and Control

Editors: Authi, Kalwant, Watson, Stephen, Kakkar, Vijay V. (Eds.)

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About this book

Recent years have seen tremendous advances in our understanding of the molecular mechanism of platelet activation. All aspects of signal transduction in platelets from the identification of surface receptors, G proteins, phospholipases, protein kinases and phosphatases, intracellular receptors for inositol phosphates, the Ca2+ regulatory machinery, cytoskeletal constituents to the control mechanism employing cyclic nucleotides has seen an explosion of information regarding their importance and for each constituent in the family of molecules to which they belong. This information has been of interest to researchers across a wide spectrum of disciplines including biochemists, pharmacologists, cell biologists and clinicians. In April 1992 an International Symposium bearing the name of this volume was organised at the Thrombosis Research Institute to bring together scientists from across the world whose common interest was the study of platelet activation and its regulation. We were particularly encouraged by the positive response from our speakers and the participants, their detailed contributions and the very lively discussions that took place throughout the two days of the symposium. Almost every aspect of signal transduction in human platelets was represented. Of the invited speakers twelve were from Europe (including the U. K. ), eight from North America and one from Japan. This volume is a compilation of chapters submitted by the speakers and represents a concise but informative picture of the present knowledge of the mechanisms of platelet activation and control.

Table of contents (20 chapters)

  • The Platelet as a Cа2+-Driven Cell: Mechanisms Which May Modulate Cа2+-Driven Responses

    Scrutton, Michael C.

    Pages 1-15

  • Agonist Receptors and G proteins as Mediators of Platelet Activation

    Brass, Lawrence F. (et al.)

    Pages 17-36

  • Regulation of Phosphoinositide-Specific Phospholipase C Activity in Human Platelets

    Nozawa, Yoshinori (et al.)

    Pages 37-47

  • RAP1B and Platelet Function

    Lapetina, Eduardo G. (et al.)

    Pages 49-55

  • Calcium Signalling and Phosphoinositide Metabolism in Platelets: Subsecond Events Revealed by Quenched-Flow Techniques

    Gear, Adrian R. L. (et al.)

    Pages 57-67

Buy this book

eBook $89.00
price for USA (gross)
  • ISBN 978-1-4615-2994-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $119.00
price for USA
  • ISBN 978-1-4613-6304-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mechanisms of Platelet Activation and Control
Editors
  • Kalwant Authi
  • Stephen Watson
  • Vijay V. Kakkar
Series Title
Advances in Experimental Medicine and Biology
Series Volume
344
Copyright
1993
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-2994-1
DOI
10.1007/978-1-4615-2994-1
Softcover ISBN
978-1-4613-6304-0
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIV, 272
Topics