Proteases in Biology and Disease

Aminopeptidases in Biology and Disease

Editors: Hooper, Nigel M., Lendeckel, Uwe (Eds.)

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About this book

Aminopeptidases in Biology and Disease provides a comprehensive review of the emerging role of aminopeptidases in a range of biological processes and disease situations. Processes as diverse as angiogenesis, antigen presentation, neuropeptide and hormone processing, pregnancy and reproduction, protein turnover, memory, inflammation, tumour growth, cancer and metastasis, blood pressure and hypertension all critically involve one or more aminopeptidases. The individual chapters have been written by experts in the field who have provided detailed accounts of the central roles played by various aminopeptidases in biology and disease.

About the authors

Nigel Hooper is Professor of Biochemistry in the School of Biochemistry and Molecular Biology at the University of Leeds, UK. He received his Ph.D in 1984 from the University of Leeds with a thesis on the "Metabolism of Neuropeptides by Cell-surface Peptidases" which stimulated his interest in proteases and paved the way for much of his subsequent research. He currently co-leads the Proteolysis Research Group at Leeds and among other topics, continues to study the structure and function of several cell-surface proteases, with a particular interest in their mode of attachment to the membrane. He has published over 90 research papers, edited 4 books and co-authored the widely acclaimed undergraduate textbook Instant Notes Biochemistry. Uwe Lendeckel is a Reader at the Institute of Experimental Internal Medicine at the Otto-von-Guericke University of Magdeburg, Germany. After his study of pharmacology and toxicology he received his Ph.D in biochemistry in 1990 from the Ernst-Moritz-Arndt University of Greifswald. His thesis on the "expression of the pro-opiomelanocortin gene in rat Islets of Langerhans and other tissues" stimulated his interest in the neuro-immunological cross-talk and the regulatory roles of cell surface proteases therein. In 1989 he joined the ectopeptidase research group at the University of Magdeburg and since then continues to study regulation of expression and the function of T cell ectopeptidases in the normal and pathological immune response, with special focus on the membrane alanyl-aminopeptidase. He has published over 40 research papers.

Table of contents (14 chapters)

  • The Puromycin-Sensitive Aminopeptidase

    Thompson, Michael W. (et al.)

    Pages 1-15

  • Methionine Aminopeptidase

    Vetro, Joseph A. (et al.)

    Pages 17-44

  • Placental Leucine Aminopeptidase

    Nomura, Seiji (et al.)

    Pages 45-59

  • Insulin-Regulated Aminopeptidase

    Yeen Chai, Siew (et al.)

    Pages 61-81

  • Leukotriene A4 Hydrolase

    Tholander, Fredrik (et al.)

    Pages 83-112

Buy this book

eBook $89.00
price for USA (gross)
  • ISBN 978-1-4419-8869-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $119.00
price for USA
  • ISBN 978-1-4613-4698-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Aminopeptidases in Biology and Disease
Editors
  • Nigel M. Hooper
  • Uwe Lendeckel
Series Title
Proteases in Biology and Disease
Series Volume
2
Copyright
2004
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4419-8869-0
DOI
10.1007/978-1-4419-8869-0
Softcover ISBN
978-1-4613-4698-2
Edition Number
1
Number of Pages
XIX, 336
Topics