Skip to main content
SpringerLink
Log in

Carcinogenesis and Mutagenesis Testing

  • Book
  • © 1984

Overview

Editors:
  1. J. F. Douglas

    1. Scientific Services Inc., Front Royal, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Contemporary Biomedicine (CB, volume 4)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (24 chapters)

  1. Front Matter

    Pages i-xviii
    Download chapter PDF

  2. The Fundamental Biology

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Mutagenesis and Other Short-Term Tests

      1. An Overview of Short-Term Testing
        • S. R. Haworth
        Pages 3-6
      2. Genetic Toxicology
        • David J. Brusick
        Pages 7-16
      3. Consequences of Genotoxic Effects
        • David J. Brusick
        Pages 17-38
      4. In Vitro Cell Transformation
        • John O. Rundell
        Pages 39-62
      5. Lung Tumors In Mice
        • R. J. M. Fry, H. P. Witschi
        Pages 63-78
      6. Tissue Genotoxic Effects
        • D. J. Koropatnick, J. J. Berman
        Pages 79-86

    3. Carcinogenesis

      1. Basic Principles of Chemical Carcinogenesis
        • J. M. Ward
        Pages 87-96
      2. Pathology of Toxic, Preneoplastic, and Neoplastic Lesions
        • J. M. Ward
        Pages 97-130
      3. Carcinogen Bioassay Design
        • J. F. Douglas
        Pages 131-155
      4. Evaluation and Interpretation of Carcinogenesis Bioassay Results
        • Cipriano Cueto Jr.
        Pages 157-181

  3. Practical Carcinogenesis and Mutagenesis Assay Methodology

    1. Front Matter

      Pages 183-183
      Download chapter PDF

    2. Gene Mutation Assays

      1. Bacterial Reverse and Forward Mutation Assays
        • S. R. Haworth
        Pages 185-197
      2. Yeast Assays in Mutagen and Carcinogen Screening
        • David J. Brusick
        Pages 199-205
      3. Mouse Lymphoma Cell Assays
        • Paul E. Kirby
        Pages 207-226
      4. Chinese Hamster Ovary Mutation Assays
        • David J. Brusick
        Pages 227-233
      5. <i>Drosophila</i> Assay Systems
        • David J. Brusick
        Pages 235-242

    3. DNA Damage and Repair Assays

      1. Detection of DNA Damage and Repair in Bacteria
        • David J. Brusick
        Pages 243-250
      2. Mammalian DNA Repair Assays
        • David J. Brusick
        Pages 251-262
Back to top

Keywords

About this book

Cancer has become the most critical health problem in the United States. It is expected that 25% of the people will develop this dread disease, and many of these will die from the malady. The causes of cancer are varied, but the best estimate available is that 70--90% arise from environmental factors. These statistics have triggered widespread governmental action along two lines: (l) An effort to identify those chemicals and conditions that give rise to malignant processes has been mounted by the Carcino­ genesis Testing Program, the National Cancer Program, and subse­ quently, the National Toxicology Program. (2) Regulatory laws have been enacted that are administered by agencies such as TSCA, FIFRA, EPA, FDA, OSHA, and so on, whose mission is to minimize public ex­ posure to carcinogens. Since direct verification that specific chemicals induce cancer in hu­ of unanticipated expo­ mans is necessarily limited to known incidences sure and is therefore rare, most chemicals are identified as carcinogens only by laboratory experiments. At present, the only accepted procedure is long-term animal bioassay, and not only are these studies expensive and time-consuming, but current worldwide resources permit the evalua­ tion of only 300-400 chemicals per year, a miniscule amount compared to what is available in the commercial world: 30,000 existing chemicals, with approximately 700 new such materials being introduced every year.

Editors and Affiliations

  • Scientific Services Inc., Front Royal, USA

    J. F. Douglas

Bibliographic Information

  • Book Title: Carcinogenesis and Mutagenesis Testing

  • Editors: J. F. Douglas

  • Series Title: Contemporary Biomedicine

  • DOI: https://doi.org/10.1007/978-1-4612-5164-4

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: The HUMANA Press Inc. 1984

  • Hardcover ISBN: 978-0-89603-042-8Published: 05 October 1984

  • Softcover ISBN: 978-1-4612-9592-1Published: 12 October 2011

  • eBook ISBN: 978-1-4612-5164-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XX, 335

  • Topics: Pathology

Publish with us

Policies and ethics

Back to top

Search

Navigation