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Ivermectin and Abamectin

  • Book
  • © 1989

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Editors:
  1. William C. Campbell

    1. Merck Institute for Therapeutic Research, Rahway, USA

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xx
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  2. Part I

    1. Chemistry

      • M. H. Fisher, H. Mrozik
      Pages 1-23

    2. Isolation and Characterization of the Producing Organism

      • R. W. Burg, E. O. Stapley
      Pages 24-32

    3. Fermentation Development and Process Improvement

      • Mary Nallin Omstead, Louis Kaplan, Barry C. Buckland
      Pages 33-54

    4. Biosynthesis

      • S. T. Chen, O. D. Hensens, M. D. Schulman
      Pages 55-72

    5. Mode of Action of Ivermectin

      • M. J. Turner, J. M. Schaeffer
      Pages 73-88

  3. Part II

    1. Toxicology

      • George R. Lankas, Lea R. Gordon
      Pages 89-112

    2. Pharmacokinetics of Ivermectin in Animals and Humans

      • David W. Fink, Arturo G. Porras
      Pages 113-130

    3. Metabolism and Tissue Residues

      • Shuet-Hing Lee Chiu, Anthony Y. H. Lu
      Pages 131-143

    4. Chemical Assay for Ivermectin in Edible Tissues

      • George V. Downing
      Pages 144-148

    5. Safety of Ivermectin in Target Animals

      • J. D. Pulliam, J. M. Preston
      Pages 149-161

    6. Environmental Aspects of Ivermectin Usage in Livestock: General Considerations

      • B. A. Halley, R. J. Nessel, A. Y. H. Lu
      Pages 162-172

    7. Environmental Aspects of Use of Ivermectin and Abamectin in Livestock: Effects on Cattle Dung Fauna

      • R. A. Roncalli
      Pages 173-181

    8. Environmental Aspects of Abamectin Use in Crop Protection

      • P. G. Wislocki, L. S. Grosso, R. A. Dybas
      Pages 182-200

    9. Worker Safety Aspects of Abamectin Use in Crop Protection

      • L. S. Grosso, R. A. Dybas, S. F. Rickard
      Pages 201-214

  4. Part III

    1. Use of Ivermectin in Cattle, Sheep, Goats, and Swine

      • G. W. Benz, R. A. Roncalli, S. J. Gross
      Pages 215-229

    2. Use of Abamectin in Cattle

      • G. W. Benz, J. L. Cox
      Pages 230-233

    3. Use of Ivermectin in Horses

      • William C. Campbell, W. H. D. Leaning, R. L. Seward
      Pages 234-244

    4. Use of Ivermectin in Dogs and Cats

      • William C. Campbell
      Pages 245-259

    5. Use of Ivermectin in Laboratory and Exotic Mammals and in Birds, Fish, and Reptiles

      • M. D. Soll
      Pages 260-286
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Keywords

About this book

Ivermectin and abamectin, members of the avermectin family of compounds, were introduced to the market in the 1980's as a veterinary antiparasitic drug and agricultural pesticide, respectively. Their acceptance and commercial success have been remarkable; both are highly effective and in worldwide use. The efficacy of ivermectin in river blindness has expanded the interest in its use in human medicine. In response to the intense scientific and industrial interest in ivermectin and abamectin and the likelihood that they will be forerunners of an expanding family of drugs, this comprehensive monograph satisfies the need for a review and synthesis of current knowledge about the use of these substances in crop protection as well as in cattle, sheep, swine, horses, dogs, cats, birds, fish, reptiles, and in man. This overview presents chemical, biochemical, and microbiological data, as well as pharmacological, safety, and environmental aspects and covers practical use of the compounds as antiparasitic and pesticide agents, as well as the available safety data that have emerged from the clinical experience with human applications.

Editors and Affiliations

  • Merck Institute for Therapeutic Research, Rahway, USA

    William C. Campbell

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