Serono Symposia USA

Genetic Models of Immune and Inflammatory Diseases

Editors: Abbas, Abul K., Flavell, Richard A. (Eds.)

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About this book

This book contains the proceedings of the Serono Symposia USA interna­ tional symposium on Genetic Models of Immune and Inflammatory Dis­ eases held on October 20 to 23, 1994, in Savannah, Georgia. The advent of methods for introducing genes into the germlines of mice, and for targeted disruption of particular genes by homologous recombination, has provided scientists in many disciplines with an extraordinarily powerful set of analyti­ cal tools. Some of the most informative applications of transgenic and gene knockout technology have been in studies of lymphocyte development and activation. The goal of this symposium was to bring together investigators using these genetic approaches for analyzing the immune system, with a view to defining common themes and novel directions. Transgenic mice have a wide variety of important applications in immu­ nology. Defined proteins can be expressed in selected tissues throughout development, thus acquiring the essential characteristic of "self" antigens. Such models have been used to study how immune responses to these artificially created "self" antigens are controlled. Antigen receptors of lym­ phocytes have been expressed as transgenes, and because lymphocytes are endowed with the unique property of allelic exclusion, such transgenic mice become essentially monospecific. Immunomodulatory agents have been expressed in defined tissues or throughout the body, providing tools for studying the functional consequences of dysregulated expression of biologi­ cal response modifiers.

Table of contents (17 chapters)

  • Intensification of Diabetes in B7-1 Transgenic Mice

    Janeway, Charles A. (et al.)

    Pages 3-15

  • A Transgenic Window on Self-Reactive T Lymphocytes

    Miller, Jacques F. A. P. (et al.)

    Pages 16-21

  • Induction and Breaking of Peripheral Tolerance

    Hämmerling, Günter J. (et al.)

    Pages 22-28

  • T-Cell Development and Tolerance in Virus-Specific Transgenic Models

    Ohashi, Pamela S.

    Pages 29-43

  • Inflammatory Disease in HLA-B27 Transgenic Rats

    Taurog, Joel D. (et al.)

    Pages 44-50

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-1-4612-2376-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.00
price for USA
  • ISBN 978-1-4612-7520-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Genetic Models of Immune and Inflammatory Diseases
Editors
  • Abul K. Abbas
  • Richard A. Flavell
Series Title
Serono Symposia USA
Copyright
1996
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York, Inc.
eBook ISBN
978-1-4612-2376-4
DOI
10.1007/978-1-4612-2376-4
Softcover ISBN
978-1-4612-7520-6
Edition Number
1
Number of Pages
XVI, 177
Topics