Cancer Markers

1. Front Matter

   Pages i-xxvii

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2. Teratocarcinoma

   • G. Barry Pierce

   Pages 1-36

3. Mouse Lymphocyte Differentiation Markers

   • Peter R. Panfili

   Pages 37-55

4. Monoclonal Immunoglobulins As Biomarkers Of Cancer

   • Alan Solomon

   Pages 57-87

5. Markers in Human Lymphoid Tumors

   • Brigid G. Leventhal, Curt I. Civin, Gregory Reaman

   Pages 89-113

6. Oncofetal Transplantation Antigens

   • Stanley E. Chism

   Pages 115-132

7. Antigens and the Major Histocompatibility Complex

   • James Forman

   Pages 133-168

8. Hormone-Secreting Tumors

   • George Griffing, Judith L. Vaitukaitis

   Pages 169-190

9. Enzymes and Isozymes in Cancer

   • Doris Balinsky

   Pages 191-224

10. Pregnancy Proteins As Tumor Markers

    • Charles H. W. Horne, Roy D. Bremner

    Pages 225-247

11. Alphafetoprotein

    • Stewart Sell

    Pages 249-293

12. Carcinoembryonic Antigen A: Chemistry and Biology

    • John E. Shively, Charles W. Todd

    Pages 295-314

13. Theoretical and Practical Considerations of the Utility of the Radioimmunoassay for Carcinoembryonic Antigen (CEA) In Clinical Medicine

    • Abraham Fuks, Joseph Shuster, Phil Gold

    Pages 315-327

14. Antigens Associated with Human Solid Tumors

    • David V. Gold, David M. Goldenberg

    Pages 329-369

15. Surface Glycolipid and Glycoprotein Antigens

    • Ganesa Yogeeswaran

    Pages 371-401

16. Lectin Interactions with Normal and Tumor Cells and the Affinity Purification of Tumor Cell Glycoproteins

    • Garth L. Nicolson

    Pages 403-443

17. Transfer RNA and Its By-Products as Tumor Markers

    • Ernest Borek

    Pages 445-462

18. Nonhistone Protein Antigens

    • Lubomir S. Hnilica, Robert C. Briggs

    Pages 463-483

19. Fibronectin

    • Erkki Ruoslahti, Edward G. Hayman, Eva Engvall

    Pages 485-505

20. Circulating Immune Complexes in Cancer

    • R. W. Baldwin, R. A. Robins

    Pages 507-531

Developmental cancer products (oncodevelopmental markers, ODM) not only serve as diagnostic and prognostic indicators but also may be used to study the nature of the carcinogenic process and the biology of tumors. For many years oncologists have searched for markers of cancer cells that would permit unequivocal recognition of cancer in contrast to noncancerous tissue. The earliest and still most widely used method of identification of cancer tissue or cells is the structural resemblance of cancer tissue to fetal or immature tissue. Pathologists not only recognize cancer by its morphologic similarity to fetal tissues, but also in many instances can relate the behavior of a given tumor to the degree of tissue differentiation. Thus, poorly differentiated tumors that resemble fetal tissue generally grow more rapidly and metastasize earlier than do well-differentiated tumors that more closely resemble adult tissue. In recent years the commonality of fetal and cancer tissue has been extended to products of tumor cells that, can be analyzed by biochemical, immunological, or physiological techniques. Increas­ ingly, products of cancer cells similar to fetal products are being identified and studied. These products range from cell-surface markers (fetal or differentiation antigens), placental proteins, hormones, and isoenzymes to a multitude of products, such as carcinoembryonic antigen (CEA), alphafetoprotein (AFP), lymphocyte markers, and nucleic acids, such as tRNA, that are produced in small amounts by v vi PREFACE continually differentiating cells in the adult but in much greater amounts by tumors.

• cancer
• carcinogenesis
• carcinoma
• cell
• classification
• embryo
• genetics
• hormones
• leukemia
• lymphoma
• melanoma
• pathogenesis
• thymus
• tissue
• tumor

"...a highly useful, concise encyclopedia providing introduction to stem cells as well as special topics in the state-of-the-art stem cell research." - Pharmaceutical Research

• Department of Pathology, University of California Medical School, San Diego, La Jolla, USA

  Stewart Sell

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