Neurodegenerative Diseases

Clinical Aspects, Molecular Genetics and Biomarkers

Editors: Scarpini, Elio, Scarpini, Elio (Eds.)

  • Covers clinical and genetic aspects, as well as biomarkers for early diagnosis and treatment
  • Translational (from bench to bedside) approach
  • Includes chapters on neurodegeneration in classically non-degenerative disorders
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About this book

This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases. Different aspects of each disease are reviewed, including clinical issues, treatments, basic discoveries (genetics and molecular biology), and translation of basic research into biomarkers for early diagnosis. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis.

Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields. 

About the authors

Daniela Galimberti, PhD

Senior Researcher

Alzheimer Center

Neurology Unit

University of Milan

Fondazione Ca’ Granda, IRCCS Ospedale Policlinico

Milan, Italy

Daniela Galimberti got her degree in Biological Sciences in 1996 and her PhD in Neurological Sciences in 2004.

She is the Chief of the Laboratory of the Alzheimer Center at the Policlinico University Hospital (Milan, Italy). Her main interests include genetics and bio-molecular aspects of neurodegenerative disorders (Alzheimer’s disease, Frontotemporal Lobar Degeneration) and demyelinating diseases (Multiple Sclerosis).

Dr. Galimberti is the Chair of the subcommittee on Dementia of the European Neurological Society.

She is author of 195 scientific articles in international peer-reviewed journals, 10 chapters in international volumes, and more than 250 contributions to conferences. He serves as reviewer for several neurological journals. She is a Senior Associate Editor of the “Journal of Alzheimer’s disease”.

Elio Scarpini, MD

Professor of Neurology

Chief of the Alzheimer Center

Neurology Unit

University of Milan

Fondazione Ca’ Granda, IRCCS Ospedale Policlinico

Milan, Italy

Elio Scarpini got his degree in Neurology in 1981 and he is professor of Neurology at the University of Milan. He is the Chief of the Alzheimer Center at the Policlinico University Hospital (Milan, Italy). His main interests include clinical and therapeutic aspects of neurodegenerative disorders (Alzheimer’s disease, Frontotemporal Lobar Degeneration) and demyelinating diseases (Multiple Sclerosis).

He is author of more than 250 scientific articles in international peer-reviewed journals, 8 chapters in international volumes, and more than 350 contributions to conferences.

He serves as reviewer for several neurological journals. He is a member of the Editorial Board of the Journal of Neurology and is an Associate Editor of the Journal of the Neurological Sciences.

Reviews

From the reviews:

“This monograph on neurodenerative diseases and animal models covers a broad spectrum of molecular biology, biomarkers, and in depth descriptions concerning Alzheimers Disease, both genetic and nongenetic. The book is of importance to neurology researchers, students, and biochemists with a research interest in Alzheimer’s Disease.” (Joseph J. Grenier, Amazon.com, May, 2014)


Table of contents (14 chapters)

  • Genetics and Epigenetics: Basic Concepts

    Fenoglio, Chiara

    Pages 1-15

  • Alzheimer’s Disease: Clinical Aspects and Treatments

    Ghezzi, Laura

    Pages 17-26

  • Autosomal Dominant Alzheimer’s Disease: Underlying Causes

    Ghani, Mahdi (et al.)

    Pages 27-47

  • Genetic Risk Factors for Alzheimer’s Disease

    Combarros, Onofre

    Pages 49-64

  • The Role of Cerebrovascular Disease in Cognitive Decline

    Verdelho, Ana

    Pages 65-76

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-1-4471-6380-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
  • ISBN 978-1-4471-6379-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA
  • ISBN 978-1-4471-7242-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Neurodegenerative Diseases
Book Subtitle
Clinical Aspects, Molecular Genetics and Biomarkers
Editors
  • Elio Scarpini
  • Elio Scarpini
Copyright
2014
Publisher
Springer-Verlag London
Copyright Holder
Springer-Verlag London
eBook ISBN
978-1-4471-6380-0
DOI
10.1007/978-1-4471-6380-0
Hardcover ISBN
978-1-4471-6379-4
Softcover ISBN
978-1-4471-7242-0
Edition Number
1
Number of Pages
XIX, 253
Number of Illustrations and Tables
6 b/w illustrations, 9 illustrations in colour
Topics