Molecular Biology of Valvular Heart Disease

Editors: Rajamannan, Nalini M. (Ed.)

  • Comprehensive clinical discussion of the biology of valvular heart disease
  • Provides discussion of the expanding field of valvular biology
  • Guides physicians on the potential medical therapies to treat valvular heart disease
  • Provides a platform for cellular targeting of valvular heart disease
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  • ISBN 978-1-4471-6350-3
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  • ISBN 978-1-4471-6349-7
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  • ISBN 978-1-4471-7240-6
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About this book

The cellular mechanisms of valvular heart disease have not been elucidated until the last decade. To date, there is no medical therapy that is FDA or CE mark approved for the treatment and/or slowing the progression of this disease. This textbook will provide the cellular basis for medical therapy. Over the past decade, research laboratories are more and more evolving into valvular biology programs from the traditional vascular biology. The science between the two disciplines, although has several similarities has unique cellular targets secondary to the embryologic derivation of the heart valve  and the hemodynamics involved in the understanding of this disorders. This textbook will be a natural progression from the recently published text Cardiac Valvular Medicine, Springer 2012. This new textbook will provide the cellular details and the more basic molecular biology approaches towards understanding the disease, providing novel cellular targets and finally developing future clinical trials in the medical treatment of valvular heart disease in the future.

About the authors

Nalini M. Rajamannan, MD has been studying the cellular biology of valvular heart disease since 1987. She has trained at the Mayo Clinic, in molecular biology, cardiology and echocardiography to develop an expertise which is translational in the approach towards valvular medicine. Her expertise has developed the initial experimental models towards studying medical therapies for this disease process. She is the chair of NHLBI/NIH working group in calcific aortic valve disease. This white paper was published in Circulation in Oct 2011. She has had NIH funding in this field since 2002 and has published 60 papers, several book chapters and the most recent textbook in Cardiac Valvular Medicine. She also has 3 patents in the field of cardiac valve signaling and pathogenesis of this disease.

Table of contents (17 chapters)

  • Calcific Aortic Valve Disease: The Role of the Stem Cell Niche

    Rajamannan, Nalini M. (et al.)

    Pages 1-12

  • In Vitro Cell Culture Model of Calcification: Molecular Regulation of Myofibroblast Differentiation to an Osteoblast Phenotype

    Rajamannan, Nalini M. (et al.)

    Pages 13-20

  • Aortic Valve Apoptosis, Cell Proliferation and Atherosclerosis in Experimental Hypercholesterolemia

    Shuvy, Mony (et al.)

    Pages 21-25

  • Experimental Model of Aortic Valve Calcification to Induce Osteoblast Differentiation

    Rajamannan, Nalini M. (et al.)

    Pages 27-33

  • Development of an Experimental Model of Mitral Valve Regurgitation via Hypertrophic Chondrocytes

    Rajamannan, Nalini M. (et al.)

    Pages 35-40

Buy this book

eBook $69.99
price for USA (gross)
  • ISBN 978-1-4471-6350-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $89.99
price for USA
  • ISBN 978-1-4471-6349-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $89.99
price for USA
  • ISBN 978-1-4471-7240-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Biology of Valvular Heart Disease
Editors
  • Nalini M. Rajamannan
Copyright
2014
Publisher
Springer-Verlag London
Copyright Holder
Springer-Verlag London
eBook ISBN
978-1-4471-6350-3
DOI
10.1007/978-1-4471-6350-3
Hardcover ISBN
978-1-4471-6349-7
Softcover ISBN
978-1-4471-7240-6
Edition Number
1
Number of Pages
XVII, 150
Number of Illustrations and Tables
10 b/w illustrations, 50 illustrations in colour
Topics