Computational Biology

Phenotypes and Genotypes

The Search for Influential Genes

Authors: Frommlet, Florian, Bogdan, Małgorzata, Ramsey, David

  • Introduces the major concepts of Quantitative Trait Loci mapping
  • Discusses the methodology of Quantitative Trait Loci mapping in experimental populations
  • Describes the methods for Genome Wide Association Studies and related multiple testing and model selection problems
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eBook $79.99
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-1-4471-5310-8
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  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $109.00
price for USA
  • ISBN 978-1-4471-5309-2
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About this book

This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed modifications of the Bayesian information criterion. Features: presents a thorough introduction to the theoretical background to studies of genetic association (both genetic and statistical); reviews the latest advances in the field; illustrates the properties of methods for mapping quantitative trait loci using computer simulations and the analysis of real data; discusses open challenges; includes an extensive statistical appendix as a reference for those who are not totally familiar with the fundamentals of statistics.

About the authors

Dr. Florian Frommlet is a researcher in the Center for Medical Statistics, Informatics, and Intelligent Systems at the Medical University of Vienna, Austria.

Dr. Małgorzata Bogdan is an Associate Professor in the Institute of Mathematics at Wrocław University, Poland.

Dr. David Ramsey is a Senior Lecturer in the Department of Operations Research at Wrocław University of Technology, Poland.

Table of contents (10 chapters)

  • Introduction

    Frommlet, Florian (et al.)

    Pages 1-8

  • A Primer in Genetics

    Frommlet, Florian (et al.)

    Pages 9-30

  • Statistical Methods in High Dimensions

    Frommlet, Florian (et al.)

    Pages 31-72

  • Statistical Methods of QTL Mapping for Experimental Populations

    Frommlet, Florian (et al.)

    Pages 73-104

  • Statistical Analysis of GWAS

    Frommlet, Florian (et al.)

    Pages 105-161

Buy this book

eBook $79.99
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-1-4471-5310-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $109.00
price for USA
  • ISBN 978-1-4471-5309-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Phenotypes and Genotypes
Book Subtitle
The Search for Influential Genes
Authors
Series Title
Computational Biology
Series Volume
18
Copyright
2016
Publisher
Springer-Verlag London
Copyright Holder
Springer-Verlag London
eBook ISBN
978-1-4471-5310-8
DOI
10.1007/978-1-4471-5310-8
Hardcover ISBN
978-1-4471-5309-2
Series ISSN
1568-2684
Edition Number
1
Number of Pages
XII, 222
Number of Illustrations and Tables
13 b/w illustrations, 20 illustrations in colour
Topics