Motor Neuron Disease

1. Front Matter

   Pages i-xviii

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2. Motor Neuron Disease: The Clinical Syndrome

   • M. Swash, M. S. Schwartz

   Pages 1-17

3. Epidemiology of Motor Neuron Disease

   • K. Kondo

   Pages 19-33

4. Familial Motor Neuron Disease

   • J. de Belleroche, P. N. Leigh, F. Clifford Rose

   Pages 35-51

5. Pathology of Motor System Disorder

   • Samuel M. Chou

   Pages 53-92

6. The Pathology of Motor Neuron Disease

   • J. E. Martin, M. Swash

   Pages 93-118

7. Alternative Approaches to the Pathology of Motor Neuron Disease

   • J. E. Martin, M. Swash

   Pages 119-137

8. The Molecular Pathology of Motor Neuron Disease

   • P. N. Leigh, O. Garofalo

   Pages 139-161

9. Neurochemistry of Motor Neuron Disease

   • S. Malessa, P. N. Leigh

   Pages 163-188

10. Calcium and Aluminium in the Chamorro Diet: Unlikely Causes of Alzheimer-Type Neurofibrillary Degeneration on Guam

    • J. C. Steele, D. B. Williams

    Pages 189-200

11. Toxicology of Motor Systems

    • P. B. Nunn

    Pages 201-218

12. Theories of Causation

    • S. H. Appel, J. I. Engelhardt, R. G. Smith, E. Stefani

    Pages 219-240

13. Neurotrophic Factors and Neurodegeneration

    • J. E. Martin

    Pages 241-258

14. Somatic Motoneurons and Descending Motor Pathways. Limbic and Non-limbic Components

    • G. Holstege

    Pages 259-330

15. Neurophysiological Changes in Motor Neuron Disease

    • M. S. Schwartz, M. Swash

    Pages 331-344

16. Clinical Pharmacology of Motor Neurons

    • R. J. Guiloff

    Pages 345-373

17. The Management of Motor Neuron Disease

    • R. Langton Hewer

    Pages 375-406

18. Clinical Trial Methodology

    • T. L. Munsat, D. Hollander, L. Finison

    Pages 407-417

19. New Therapeutic Approaches: Rationale and Results

    • H. Mitsumoto

    Pages 419-441

20. Living with Motor Neuron Disease

    • P. N. Leigh, Michael Swash

    Pages 443-457

Here is the first book to provide a comprehensive overview of the clinical, pathological, and research aspects of motor neuron disease (MND). The text contains all essential features of the anatomy, physiology, pharmacology and toxicology of the motor system, a full description of MND and its variants, as well as historical developments and a review of the current concepts and controversies. This book comes at a time of increasing interest in neurodegenerative disorders and MND in particular. It will prove a key reference book with an integrated overview of the field, and will be indispensable to practicing neurologists, researchers, and all those with an interest in MND.

• Alzheimer's disease
• Alzheimer´s disease
• Parkinson
• anatomy
• brainstem
• cortex
• muscle
• nervous system
• neurochemistry
• neurodegenerative disorders
• neurons
• neuropathology
• neuropeptides
• physiology
• spinal cord

"This book is worthwhile to every neurologist and particularly those interested in ALS. It is an interesting book to everybody involved in research on motor neuron diseases. it certainly is one of the better volumes on MND available." Acta Neurologica Belgica

• University Department of Neurology, Institute of Psychiatry and Kings College School of Medicine and Dentistry, London, UK

  P. N. Leigh

• Department of Neurology, The Royal London Hospital, London, UK

  Michael Swash

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