Energy Balance and Cancer

Insulin Resistance and Cancer

Epidemiology, Cellular and Molecular Mechanisms and Clinical Implications

Editors: Fantus, I. George (Ed.)

  • In-depth detail of basic concepts of insulin and cancer and how they interact.
  • Reviews the epidemiological associations between insulin resistance and cancer.
  • Focuses primarily on breast cancer as a key and significant model for cancer research and insulin.
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eBook $199.00
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  • ISBN 978-1-4419-9911-5
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Hardcover $259.00
price for USA
  • ISBN 978-1-4419-9910-8
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  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
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  • ISBN 978-1-4614-2818-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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About this book

This book reviews the epidemiological associations between insulin resistance and cancer. This is followed by reviews of animal models which support this relationship and provide insight into potential mechanisms. Several chapters then provide detailed examination of the cellular and molecular changes characterizing the insulin resistant state, such as hyperinsulinemia, abnormal metabolism and hormone signaling, and how these interact with various tumor characteristics. For example some tumors present increased quantities of the fetal form of the insulin receptor, unique regulation of oxidative (Krebs’ cycle) metabolism (Warburg effect), as well as mutations in various relevant signaling pathways. Finally, the clinical implications of these data are integrated with considerations of insulin “sensitization” and potential metabolic interventions to prevent and treat cancer. It should be noted that while a number of cancers are associated with obesity the authors here have focused primarily on breast cancer as a key and significant model.

Table of contents (12 chapters)

  • Insulin and the Physiology of Carbohydrate Metabolism

    Pereira, Sandra (et al.)

    Pages 1-52

  • Insulin/IGF-1 Signaling Nodes and their Role in Carcinogenesis

    Taniguchi, Cullen M. (et al.)

    Pages 53-76

  • The Mechanisms and Impact of Obesity and Insulin Resistance on Breast Cancer Incidence

    Clegg, Deborah J.

    Pages 77-99

  • Obesity and Cancer: Epidemiology

    Irwin, Melinda L.

    Pages 101-110

  • Insulin, Insulin Resistance, and Cancer Associations

    Lipscombe, Lorraine

    Pages 111-140

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-1-4419-9911-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-1-4419-9910-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4614-2818-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Insulin Resistance and Cancer
Book Subtitle
Epidemiology, Cellular and Molecular Mechanisms and Clinical Implications
Editors
  • I. George Fantus
Series Title
Energy Balance and Cancer
Series Volume
1
Copyright
2011
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-9911-5
DOI
10.1007/978-1-4419-9911-5
Hardcover ISBN
978-1-4419-9910-8
Softcover ISBN
978-1-4614-2818-3
Series ISSN
2199-2622
Edition Number
1
Number of Pages
XII, 300
Topics