Targeted Drug Strategies for Cancer and Inflammation

Editors: Jackman, Ann L., Leamon, Christopher P. (Eds.)

  • Describes the emerging range of therapeutics with the potential to more precisely target pathologic tissue
  • Recounts progress in the use of folates to transport antifolate drugs such as raltitrexed and pemetrexed that block the mechanisms of cancer
  • Covers development of FR-targeted antifolate drugs and folate conjugates bearing a range of payloads (including cytotoxic drugs)
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eBook $199.00
price for USA (gross)
  • ISBN 978-1-4419-8417-3
  • Digitally watermarked, DRM-free
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  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
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  • ISBN 978-1-4419-8416-6
  • Free shipping for individuals worldwide
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Softcover $259.00
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  • ISBN 978-1-4899-8886-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The discoveries highlighted in this book parallel the emergence of innovative “molecular targeted” small molecules and monoclonal antibodies, i.e. agents that target proteins within highly activated signal transduction pathways that control proliferation.  Many of the tumor-targeted strategies described within cross the boundaries between what’s considered to be “molecular targeted” versus conventional systemic therapy.  However, the main theme of this volume is the folate receptor (FR), with much of the content focused on its basic biology and regulation as well as its exploitation for targeted therapy and diagnostic imaging.

Table of contents (12 chapters)

  • Biological Role, Properties, and Therapeutic Applications of the Reduced Folate Carrier (RFC-SLC19A1) and the Proton-Coupled Folate Transporter (PCFT-SLC46A1)

    Matherly, Larry H. (et al.)

    Pages 1-34

  • Folate Receptors and Therapeutic Applications

    Kamen, Barton A.

    Pages 35-47

  • Hormonal Control of Folate Receptor Genes

    Gonit, Mesfin (et al.)

    Pages 49-63

  • Folate Receptor-Targeted Radionuclide Imaging Agents

    Müller, Cristina (et al.)

    Pages 65-92

  • Folate Receptor Targeted Thymidylate Synthase Inhibitors

    Jackman, Ann L. (et al.)

    Pages 93-117

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-1-4419-8417-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-1-4419-8416-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4899-8886-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Targeted Drug Strategies for Cancer and Inflammation
Editors
  • Ann L. Jackman
  • Christopher P. Leamon
Copyright
2011
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-8417-3
DOI
10.1007/978-1-4419-8417-3
Hardcover ISBN
978-1-4419-8416-6
Softcover ISBN
978-1-4899-8886-7
Edition Number
1
Number of Pages
XI, 254
Topics