Current Cancer Research

Molecular Determinants of Radiation Response

Editors: DeWeese, Theodore L., Laiho, Marikki (Eds.)

  • Includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins
  • Presents comprehensive discussions on where and how specific alterations in function of these pathways and proteins result in substantive modifications of cellular response to DNA injury
  • Offers a timely and relevant text for basic and translational researchers
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eBook $199.00
price for USA (gross)
  • ISBN 978-1-4419-8044-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-1-4419-8043-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4614-2832-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The DNA of mammalian cells is constantly under assault from both endogenous and exogenous sources.  Ionizing radiation is one of the most important sources of genomic injury because of its ability to inflict substantial cellular damage that is both therapeutic as well as mutagenic.  Mammalian cells have evolved an impressive array of DNA damage response mechanisms that are called upon to respond to and repair radiation-induced DNA injury that allow cells to survive with DNA fidelity intact.  Contemporary oncologic research and patient management demand a thorough understanding of these DNA damage response processes as well as some of the important environmental conditions like hypoxia in which cells exist such that strategies that subvert these survival processes can be considered and exploited for therapeutic gain.

Molecular Determinants of Radiation Response includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins.  The chapters include comprehensive discussions on where and how specific alterations in function of these pathways and proteins result in substantive modifications of cellular response to DNA injury.   The authors have done a wonderful job in providing meaningful reviews, with appropriate detail and scope for both the well informed reader as well as the novice looking for new information.  Given the importance of therapies that induce DNA injury in the management of human disease, this book is timely and relevant for basic and translational researchers, as well as clinicians alike.

Table of contents (12 chapters)

  • H2AX in DNA Damage Response

    Redon, Christophe E. (et al.)

    Pages 3-33

  • DNA Damage Signaling Downstream of ATM

    Bunz, Fred

    Pages 35-52

  • Checkpoint Control Following Radiation Exposure

    Lobrich, Markus (et al.)

    Pages 53-77

  • Chromatin Responses to DNA Damage

    Falbo, Karina (et al.)

    Pages 79-100

  • Caenorhabditis elegans Radiation Responses

    Bailly, Aymeric (et al.)

    Pages 101-123

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-1-4419-8044-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-1-4419-8043-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4614-2832-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Determinants of Radiation Response
Editors
  • Theodore L. DeWeese
  • Marikki Laiho
Series Title
Current Cancer Research
Copyright
2011
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-8044-1
DOI
10.1007/978-1-4419-8044-1
Hardcover ISBN
978-1-4419-8043-4
Softcover ISBN
978-1-4614-2832-9
Series ISSN
2199-2584
Edition Number
1
Number of Pages
XVI, 276
Topics