Advances in Experimental Medicine and Biology

Adhesion‑GPCRs

Structure to Function

Editors: Yona, Simon, Stacey, Martin (Eds.)

  • Includes coverage of the evolution of the adhesion-GPCR genes in several species
  • Explores how this proteolytic cleavage was identified as an intrinsic protein modification process in the majority adhesion-GPCRs
  • Describes the expression of adhesion-GPCRs within the male reproductive tract and reviews their potential contribution in reproductive competence
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eBook $199.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-1-4419-7913-1
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  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4419-7912-4
  • Free shipping for individuals worldwide
  • This title is currently reprinting. You can pre-order your copy now.
About this book

Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodopsin, adhesion, frizzled/taste2 and secretin receptors. The adhesion-GPCR family 2 can be further subdivided into eight groups. The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation.

About the authors

Simon Yona, PhD, graduated from Kings College, University London with a BSc in Physiology and a MSc in Pharmacology, before completing a PhD with Prof. R.J. Flower FRS and Prof. M. Perretti, at St. Bartholomew’s Hospital, University of London. Following his doctorate Simon took up a Postdoctoral Research position with Prof. S. Gordon FRS, at the Sir William Dunn School of Pathology, University of Oxford, where he investigated the roles and functions of the leukocyte restricted adhesion‑GPCRs. Dr. Yona moved from Oxford to join the group of Prof. S. Jung, at the Weizmann Institute of Science, Rehovot, when he was awarded a Federation of European Biochemical Societies, International Fellowship. Currently he is investigating the developmental profile of mononuclear phagocytes in a number of pathologies. Martin Stacey, DPhil (Oxon), graduated from Hertford College, University of Oxford with an MBiochem before completing a DPhil in the laboratory of Prof. S. Gordon FRS. He continued working at the Sir William Dunn School of Pathology for a number of years where he cloned and characterized leukocyte adhesion‑GPCRs and demonstrated the existence of their cell surface ligands. More recently, Dr. Stacey has been appointed as a Lecturer of Immunology, at the University of Leeds where his laboratory focuses on adhesion‑GPCRs and role of myeloid cells in human disease.

Table of contents (16 chapters)

  • The Adhesion GPCRs; Gene Repertoire, Phylogeny and Evolution

    Schiöth, Helgi B. (et al.)

    Pages 1-13

  • 7TM-Cadherins: Developmental Roles and Future Challenges

    Formstone, Caroline J.

    Pages 14-36

  • Latrophilin Signalling in Tissue Polarity and Morphogenesis

    Langenhan, Tobias (et al.)

    Pages 37-48

  • GPS Proteolytic Cleavage of Adhesion-GPCRs

    Lin, Hsi-Hsien (et al.)

    Pages 49-58

  • The Latrophilins, “Split-Personality” Receptors

    Silva, John-Paul (et al.)

    Pages 59-75

Buy this book

eBook $199.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-1-4419-7913-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4419-7912-4
  • Free shipping for individuals worldwide
  • This title is currently reprinting. You can pre-order your copy now.
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Bibliographic Information

Bibliographic Information
Book Title
Adhesion‑GPCRs
Book Subtitle
Structure to Function
Editors
  • Simon Yona
  • Martin Stacey
Series Title
Advances in Experimental Medicine and Biology
Series Volume
706
Copyright
2010
Publisher
Springer US
Copyright Holder
Landes Bioscience and Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-7913-1
DOI
10.1007/978-1-4419-7913-1
Hardcover ISBN
978-1-4419-7912-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XXI, 199
Topics