Characterization of Protein Therapeutics using Mass Spectrometry

Editors: Chen, Guodong (Ed.)

  • First book to focus on characterization by mass spectrometry of protein drugs
  • Edited by a well-known expert with strong ties to pharmaceutical industry and analytical chemistry
  • Internationally recognized contributors who are top experts in the field
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eBook $139.00
price for USA (gross)
  • ISBN 978-1-4419-7862-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.00
price for USA
  • ISBN 978-1-4419-7861-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover n/a
  • ISBN 978-1-4899-7364-1
  • Free shipping for individuals worldwide
About this book

This book highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies. As one of the most frequently utilized analytical techniques in pharmaceutical research and development, mass spectrometry has been widely used in the characterization of protein therapeutics due to its analytical sensitivity, selectivity, and specificity. This book begins with an overview of mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies, quantitative approaches, followed by studies involving characterization of process related protein drug impurities/degradants, metabolites, higher order structures of protein therapeutics. Both general practitioners in pharmaceutical research and specialists in analytical sciences will benefit from this book that details step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development.

About the authors

GUODONG CHEN, PHD, has extensive pharmaceutical research experience in major pharmaceutical companies, including Eli Lilly and Company, Schering-Plough and Bristol-Myers Squibb. Currently, he heads the analytical/mass spectrometry group at Bristol-Myers Squibb’s Princeton site in support of drug discovery programs and development projects in small molecule pharmaceuticals and biologics. He has over 65 research publications in peer-reviewed journals and book chapters, and three edited/co-edited books in pharmaceutical analysis. His other contributions to the scientific community include over 80 presentations at scientific conferences and academic institutes; service as a short course instructor, as session chair at various scientific forums, and as a reviewer for journals. He received his Ph.D. in Analytical Chemistry from Purdue University under the direction of Professor R. Graham Cooks. 

Table of contents (10 chapters)

  • Introduction to Protein Mass Spectrometry

    Cotte-Rodriguez, Ismael (et al.)

    Pages 1-58

  • Quantitative Analysis of Therapeutic and Endogenous Peptides using LC/MS/MS Methods

    Chambers, Erin E.

    Pages 59-94

  • The Development and Implementation of LC/MS-Based Bioanalytical Methods for the Quantification of Protein Therapeutics in Drug Discovery

    Olah, Timothy V. (et al.)

    Pages 95-115

  • Post-Translationally Modified Proteins: Glycosylation and Disulfide Bond Formation

    Tsarbopoulos, Anthony (et al.)

    Pages 117-162

  • Mass Spectrometric Characterization in Protein Therapeutics Discovery

    Mo, Jingjie (et al.)

    Pages 163-205

Buy this book

eBook $139.00
price for USA (gross)
  • ISBN 978-1-4419-7862-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.00
price for USA
  • ISBN 978-1-4419-7861-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover n/a
  • ISBN 978-1-4899-7364-1
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Characterization of Protein Therapeutics using Mass Spectrometry
Editors
  • Guodong Chen
Copyright
2013
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4419-7862-2
DOI
10.1007/978-1-4419-7862-2
Hardcover ISBN
978-1-4419-7861-5
Softcover ISBN
978-1-4899-7364-1
Edition Number
1
Number of Pages
X, 404
Topics