Folding for the Synapse

Editors: Wyttenbach, Andreas, O'Connor, Vincent (Eds.)

  • Introduces important concepts of folding machineries
  • Gives examples of the biological relevance of further chaperone functions
  • Addresses the current view on how protein folding and misfolding contribute to synapse function and dysfunction
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eBook $229.00
price for USA (gross)
  • ISBN 978-1-4419-7061-9
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  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
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  • ISBN 978-1-4419-7060-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-4899-8222-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Folding for the Synapse addresses the current view on how protein folding/misfolding and its regulation by molecular chaperones contribute to synapse function and dysfunction. Molecular chaperones control de novo protein folding. However, there is increasing awareness that chaperones physiologically function to regulate protein-protein interaction cascades. This book will introduce the concept of folding machineries and also give examples of the biological relevance of further chaperone modality. Chaperones prevent misfolded proteins from accumulating into toxic intra-or extracellular aggregates in Alzheimer’s, Parkinson’s, Huntington’s, prion, and motor neuron diseases (proteinopathies). The various disease-defining protein aggregates in these proteinopathies are indicative of overstretched chaperone-and altered protein degradation systems. The consequence of this for neuronal function is discussed in several contributing chapters. Synapses regulate cell-to-cell communication in the nervous system as relatively discrete compartments that are dysfunctional during proteinopathies. Due to their partial autarky, synapses have evolved intrinsic protein folding and homeostatic capabilities that are discussed in the book.

The book servesced undergraduates, graduate students and (clinical) neuroscientists who want to develop an understanding of protein folding in health and disease.

About the Editors:
Dr. Andreas Wyttenbach holds a lectureship in Neuroscience at the University of Southampton (UK). After graduating in Biology at the University of Basel (Switzerland) he completed a PhD in Genetics and Evolution (University of Lausanne, Switzerland). During his postdoctoral research in the Departments of Medical Genetics and Biochemistry at the University of Cambridge (UK), he became inspired by the question of how protein misfolding in the CNS causes neuronal death, associated with neurological diseases. His current research concentrates on understanding how protein aggregation damages cells, with the motivation to provide a basis for therapeutic approaches that could prevent neurodegeneration.

Dr. Vincent O’Connor holds a readership at the University of Southampton. After his undergraduate studies in Physiology and Biochemistry at Reading University (UK), he trained at University College London (UK), graduating with a PhD in Neurochemistry. His postdoctoral time was spent at the Max Planck Institute for Brain Research (Frankfurt, Germany) and the National Institute for Medical Research (London, UK) investigating mechanisms of neurotransmitter release and synaptic plasticity. His current efforts focus on translating the knowledge of basic synaptic mechanisms into understanding CNS disease processes and the concept of “synaptopathies”

Table of contents (15 chapters)

  • Folding for the Synapse

    Wyttenbach, Andreas (et al.)

    Pages 1-6

  • Protein Aggregation: Opposing Effects of Chaperones and Crowding

    Ellis, R. John

    Pages 9-34

  • Molecular Chaperones as Facilitators of Protein Degradation

    Höhfeld, Jörg (et al.)

    Pages 35-48

  • The Small Heat-Shock Proteins: Cellular Functions and Mutations Causing Neurodegeneration

    d’Ydewalle, C. (et al.)

    Pages 49-77

  • Keeping it Together. Axonal Transport to the Synapse and the Effects of Molecular Chaperones in Health and Disease

    Sinadinos, Christopher (et al.)

    Pages 81-103

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-4419-7061-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-4419-7060-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-4899-8222-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Folding for the Synapse
Editors
  • Andreas Wyttenbach
  • Vincent O'Connor
Copyright
2011
Publisher
Springer US
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-7061-9
DOI
10.1007/978-1-4419-7061-9
Hardcover ISBN
978-1-4419-7060-2
Softcover ISBN
978-1-4899-8222-3
Edition Number
1
Number of Pages
VIII, 318
Topics